Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.41 |
| ▸ | PKLR | P30613 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 9/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12818476 | 0.86 | PKM (0.42) | PKMPKLRKDM2BLMNAALDH1A1 | |
| SCHEMBL12818489 | 0.84 | PKM (0.42) | PKMPKLRKDM2BLMNAALDH1A1 | |
| SCHEMBL12818604 | 0.84 | PKM (0.40) | PKMPKLRKDM2BLMNAALDH1A1 | |
| SCHEMBL1815577 | 0.84 | PGR (0.38) | PKMLMNAMEN1MAPTKMT2A | |
| SCHEMBL12817927 | 0.83 | PKM (0.40) | PKMPKLRKDM2BLMNAALDH1A1 | |
| SCHEMBL12818498 | 0.83 | PKM (0.41) | PKMPKLRKDM2BLMNAALDH1A1 | |
| SCHEMBL12817932 | 0.83 | PKM (0.40) | PKMPKLRKDM2BLMNAALDH1A1 | |
| SCHEMBL12818706 | 0.83 | PKM (0.45) | PKMPKLRKDM2BLMNAALDH1A1 | |
| SCHEMBL12818787 | 0.82 | PKM (0.41) | PKMPKLRKDM2BLMNAALDH1A1 | |
| SCHEMBL12818581 | 0.82 | PKM (0.39) | PKMPKLRKDM2BLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | claimed |
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |