Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | PKLR | P30613 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12818489 | 0.85 | PKM (0.42) | PKMPKLRLMNASMN1; SMN2HTT | |
| SCHEMBL12817802 | 0.84 | LMNA (0.42) | PKMPKLRLMNASMN1; SMN2HTT | |
| SCHEMBL12818373 | 0.84 | SMN1; SMN2 (0.42) | PKMPKLRLMNASMN1; SMN2HTT | |
| SCHEMBL12818380 | 0.84 | LMNA (0.42) | PKMPKLRLMNASMN1; SMN2HTT | |
| SCHEMBL12818787 | 0.83 | PKM (0.41) | PKMPKLRLMNASMN1; SMN2KDM2B | |
| SCHEMBL12818703 | 0.83 | PKM (0.41) | PKMPKLRLMNASMN1; SMN2HTT | |
| SCHEMBL12818343 | 0.83 | LMNA (0.41) | PKMPKLRLMNASMN1; SMN2HTT | |
| SCHEMBL12819198 | 0.83 | LMNA (0.41) | PKMPKLRLMNASMN1; SMN2HTT | |
| SCHEMBL12818994 | 0.83 | PGR (0.39) | PKMPKLRSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL12818394 | 0.83 | LMNA (0.41) | PKMPKLRLMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | claimed |
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |