Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CPT2 | P23786 | 2/20 | 0.34 |
| ▸ | CPT1A | P50416 | 2/20 | 0.34 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12817717 | 0.88 | GAA (0.40) | GAAATMPOLBDYRK1ACNR1 | |
| SCHEMBL12817972 | 0.86 | GAA (0.40) | GAAATMPOLBDYRK1ACNR1 | |
| SCHEMBL12818258 | 0.84 | GAA (0.39) | GAAATMPOLBDYRK1ACYP11B1 | |
| SCHEMBL12817583 | 0.83 | CYP11B1 (0.40) | GAACYP11B1CYP11B2CNR1CNR2 | |
| SCHEMBL1819022 | 0.82 | CYP11B1 (0.44) | CYP11B1CYP11B2CNR1CNR2CPT2 | |
| SCHEMBL1819499 | 0.82 | PAX8 (0.44) | CYP11B1CYP11B2CNR1CNR2CPT2 | |
| SCHEMBL12817860 | 0.81 | CYP11B1 (0.44) | CYP11B1CYP11B2CNR1CNR2CPT2 | |
| SCHEMBL12818513 | 0.80 | CYP11B1 (0.48) | CYP11B1CYP11B2CNR1CNR2DRD2 | |
| SCHEMBL12818704 | 0.80 | CYP11B1 (0.48) | GAACYP11B1CYP11B2CNR1CNR2 | |
| SCHEMBL12817730 | 0.80 | GAA (0.42) | GAAATMPOLBDYRK1ACYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | claimed |
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |