Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CPT2 | P23786 | 2/20 | 0.32 |
| ▸ | CPT1A | P50416 | 2/20 | 0.32 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12817972 | 0.85 | GAA (0.40) | GAAATMPOLBCNR1CNR2 | |
| SCHEMBL12818687 | 0.84 | PKM (0.40) | GAAATMPOLBCPT1ACPT1B | |
| SCHEMBL12818942 | 0.84 | GAA (0.42) | GAAATMPOLBCNR1CNR2 | |
| SCHEMBL12817717 | 0.83 | GAA (0.40) | GAAATMPOLBCNR1CNR2 | |
| SCHEMBL12817855 | 0.80 | KDM2B (0.37) | POLBCNR1CNR2CPT2CPT1A | |
| SCHEMBL12818239 | 0.80 | PKM (0.41) | GAAKDM4ECPT2CPT1ACPT1B | |
| SCHEMBL12817711 | 0.78 | GCK (0.36) | GAACNR1CNR2CPT2CPT1A | |
| SCHEMBL12817775 | 0.78 | GAA (0.40) | GAAATMPOLBCNR1CNR2 | |
| SCHEMBL12818267 | 0.77 | CA2 (0.32) | CNR1CNR2KDM4ECPT2CPT1A | |
| SCHEMBL12818910 | 0.77 | BRD4 (0.44) | GAAATMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | claimed |
| WO-2012130306-A1 | BICYCLIC 2,3-DIHYRDOBENZAZINE COMPOUNDS FOR USE IN THERAPY | ELARA PHARMACEUTICALS GMBH (DE) | 2012-10-04 | — | — | WO | disclosed |