Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RHOA | P61586 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11698533 | 0.89 | CYP3A4 (0.41) | ALDH1A1PTPRCCYP3A4KDM4ETSHR | |
| SCHEMBL8985122 | 0.82 | GABRA1 (0.50) | ALDH1A1GABRA1GABRB2CYP2D6TACR1 | |
| SCHEMBL11011645 | 0.82 | GABRA1 (0.41) | ALDH1A1GABRA1GABRB2CYP3A4CYP2D6 | |
| SCHEMBL5880773 | 0.80 | CYP3A4 (0.35) | ALDH1A1PTPRCCYP3A4KDM4ETSHR | |
| SCHEMBL22963887 | 0.80 | CYP3A4 (0.35) | ALDH1A1PTPRCCYP3A4KDM4ETSHR | |
| SCHEMBL5881107 | 0.80 | CYP3A4 (0.39) | ALDH1A1CYP3A4KDM4ETSHRHSD17B10 | |
| SCHEMBL9862238 | 0.80 | KDM4E (0.42) | ALDH1A1CYP3A4KDM4ETSHRMAPT | |
| SCHEMBL3178902 | 0.80 | IDO1 (0.52) | ALDH1A1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL1906074 | 0.80 | ALDH1A1 (0.38) | ALDH1A1PTPRCCYP3A4KDM4ETSHR | |
| SCHEMBL9479917 | 0.80 | IDO1 (0.52) | ALDH1A1NPSR1LMNAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11072632-B2 | Inhibitors of 17β-HSD1, 17β-HSD3 and 17β-HSD10 | UNIVERSITé LAVAL (CA) | 2021-07-27 | — | — | US | disclosed |
| US-20140088053-A1 | INHIBITORS OF 17Beta-HSD1, 17Beta-HSD3 AND 17Beta-HSD10 | UNIVERSITé LAVAL (CA) | 2014-03-27 | — | — | US | disclosed |
| EP-2688901-A1 | INHIBITORS OF 17ß-HSD1, 17ß-HSD3 AND 17ß-HSD10 | Université Laval (CA) | 2014-01-29 | — | — | EP | disclosed |
| WO-2012129673-A1 | INHIBITORS OF 17ß-HSD1, 17ß-HSD3 AND 17ß-HSD10 | UNIVERSITE LAVAL (CA) | 2012-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11072632-B2 | Inhibitors of 17β-HSD1, 17β-HSD3 and 17β-HSD10 | HSD17B11, HSD17B3, HSD17B1 | ALDH1A1 104/4885PTPRC 3221/4885GABRA1 1702/4885 |
| US-20140088053-A1 | INHIBITORS OF 17Beta-HSD1, 17Beta-HSD3 AND 17Beta-HSD10 | HSD17B11, HSD17B1, HSD17B3 | ALDH1A1 140/4885PTPRC 3643/4885GABRA1 1763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.