Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 2/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12821922 | 0.88 | FGFR1 (0.54) | FGFR1CHEK2HPGDALDH1A1MAPT | |
| SCHEMBL12822123 | 0.77 | FGFR1 (0.78) | FGFR1HPGDALDH1A1THRBMAPK1 | |
| SCHEMBL4241025 | 0.76 | HRH1 (0.62) | CHEK2ALDH1A1HRH1LMNACASP3 | |
| SCHEMBL12822160 | 0.75 | FGFR1 (0.62) | FGFR1CHEK2HPGDALDH1A1THRB | |
| SCHEMBL3844513 | 0.74 | FGFR1 (0.76) | FGFR1HPGDMAPTTP53THRB | |
| Hydrochloric Acid SCHEMBL7986276 | 0.74 | FGFR1 (0.97) | FGFR1HPGDALDH1A1MAPK1HTT | |
| SCHEMBL14852471 | 0.73 | NEK2 (0.51) | FGFR1CHEK2HPGDALDH1A1MAPT | |
| SCHEMBL12817507 | 0.73 | FGFR1 (0.84) | FGFR1HPGDTHRB | |
| SCHEMBL12822193 | 0.71 | FGFR1 (0.71) | FGFR1HPGDTHRBDYRK1A | |
| SCHEMBL24075041 | 0.71 | NR4A2 (0.60) | FGFR1ALDH1A1MAPTTHRBSENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012131501-A1 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AS COT KINASE INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2012-10-04 | — | — | WO | claimed |