Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12822215 | 0.88 | FGFR1 (0.58) | FGFR1CHEK2ALDH1A1MAPTTP53 | |
| SCHEMBL12822123 | 0.74 | FGFR1 (0.78) | FGFR1ALDH1A1HPGDTHRBMAPK1 | |
| SCHEMBL5641389 | 0.72 | CHEK2 (0.71) | CHEK2ALDH1A1HPGD | |
| SCHEMBL12822160 | 0.72 | FGFR1 (0.62) | FGFR1CHEK2ALDH1A1HPGDTHRB | |
| SCHEMBL3844513 | 0.71 | FGFR1 (0.76) | FGFR1MAPTTP53HPGDTHRB | |
| Hydrochloric Acid SCHEMBL7986276 | 0.71 | FGFR1 (0.97) | FGFR1ALDH1A1HPGDMAPK1HTT | |
| SCHEMBL3340487 | 0.70 | MAPK14 (0.48) | ROCK1 | |
| SCHEMBL20165033 | 0.70 | ALDH1A1 (0.57) | ALDH1A1ROCK1 | |
| SCHEMBL20165032 | 0.70 | ALDH1A1 (0.57) | ALDH1A1ROCK1 | |
| SCHEMBL12817507 | 0.70 | FGFR1 (0.84) | FGFR1HPGDTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012131501-A1 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AS COT KINASE INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2012-10-04 | — | — | WO | claimed |