Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.69 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.58 |
| ▸ | CDC7 | O00311 | 1/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | PAK4 | O96013 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | PRKCG | P05129 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1456959 | 0.85 | ROCK2 (0.58) | ROCK2NPC1RAB9AROCK1 | |
| SCHEMBL12824530 | 0.85 | ROCK2 (0.67) | ROCK2NPC1RAB9AROCK1CDC7 | |
| SCHEMBL29099826 | 0.85 | NPC1 (0.66) | ROCK2NPC1RAB9AROCK1MEN1 | |
| SCHEMBL20661207 | 0.84 | ROCK2 (0.67) | ROCK2NPC1RAB9AROCK1MEN1 | |
| SCHEMBL20661247 | 0.84 | ROCK2 (0.67) | ROCK2NPC1RAB9AROCK1MEN1 | |
| SCHEMBL20661204 | 0.84 | ROCK2 (0.67) | ROCK2NPC1RAB9AROCK1MEN1 | |
| SCHEMBL9883271 | 0.84 | ROCK2 (0.69) | ROCK2NPC1RAB9AROCK1CDC7 | |
| SCHEMBL19886640 | 0.82 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL20661272 | 0.81 | ROCK2 (0.70) | ROCK2NPC1RAB9AROCK1 | |
| SCHEMBL20661257 | 0.80 | ROCK2 (0.71) | ROCK2NPC1RAB9AROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295412-A1 | Indazole compounds useful as protein kinase inhibitors | Vertex Pharmaceuticals Incorporated (US) | 2011-03-16 | — | — | EP | disclosed |