Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 19/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20661272 | 0.91 | ROCK2 (0.70) | ROCK2NPC1RAB9AROCK1 | |
| SCHEMBL20661257 | 0.89 | ROCK2 (0.71) | ROCK2NPC1RAB9AROCK1 | |
| SCHEMBL20661207 | 0.87 | ROCK2 (0.67) | ROCK2NPC1RAB9AROCK1 | |
| SCHEMBL20661204 | 0.87 | ROCK2 (0.67) | ROCK2NPC1RAB9AROCK1 | |
| SCHEMBL20661247 | 0.87 | ROCK2 (0.67) | ROCK2NPC1RAB9AROCK1 | |
| SCHEMBL5858615 | 0.86 | ROCK2 (0.55) | ROCK2NPC1RAB9AROCK1 | |
| SCHEMBL12824525 | 0.85 | ROCK2 (0.69) | ROCK2NPC1RAB9AROCK1 | |
| SCHEMBL29099826 | 0.82 | NPC1 (0.66) | ROCK2NPC1RAB9AROCK1 | |
| SCHEMBL20661202 | 0.79 | ROCK2 (0.66) | ROCK2NPC1RAB9AROCK1 | |
| SCHEMBL20661265 | 0.78 | ROCK2 (0.67) | ROCK2NPC1RAB9AROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295413-A1 | Indazole compounds useful as protein kinase inhibitors | Vertex Pharmaceuticals Incorporated (US) | 2011-03-16 | — | — | EP | disclosed |
| EP-2295412-A1 | Indazole compounds useful as protein kinase inhibitors | Vertex Pharmaceuticals Incorporated (US) | 2011-03-16 | — | — | EP | disclosed |
| US-7041687-B2 | Indazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-05-09 | — | — | US | disclosed |
| US-20040009968-A1 | Indazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED | 2004-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040009968-A1 | Indazole compounds useful as protein kinase inhibitors | PRKD3, PDPK1, PDK1 | ROCK2 6/4885NPC1 911/4885RAB9A 680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.