Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 15/20 | 0.67 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.64 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.64 |
| ▸ | CLK2 | P49760 | 2/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.64 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.64 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.64 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.64 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.64 |
| ▸ | CDC7 | O00311 | 1/20 | 0.64 |
| ▸ | PLK4 | O00444 | 1/20 | 0.64 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.64 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.64 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.64 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.64 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1457361 | 0.86 | ROCK2 (0.63) | ROCK2ROCK1PRKD3MAP4K4RPS6KB1 | |
| SCHEMBL12824525 | 0.85 | ROCK2 (0.69) | ROCK2ROCK1PRKD3MAP4K4RPS6KB1 | |
| SCHEMBL9883271 | 0.84 | ROCK2 (0.69) | ROCK2ROCK1PRKD3MAP4K4RPS6KB1 | |
| SCHEMBL1456516 | 0.84 | ROCK2 (0.53) | ROCK2ROCK1PRKD3MAP4K4RPS6KB1 | |
| SCHEMBL5858615 | 0.84 | ROCK2 (0.55) | ROCK2ROCK1PRKD3MAP4K4RPS6KB1 | |
| SCHEMBL29099870 | 0.84 | ROCK2 (0.55) | ROCK2ROCK1PRKD3MAP4K4RPS6KB1 | |
| SCHEMBL20661261 | 0.82 | ROCK2 (0.65) | ROCK2ROCK1PRKD3MAP4K4RPS6KB1 | |
| SCHEMBL20661235 | 0.82 | ROCK2 (0.67) | ROCK2ROCK1PRKD3MAP4K4RPS6KB1 | |
| SCHEMBL19886625 | 0.80 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL29431387 | 0.80 | ROCK2 (0.74) | ROCK2ROCK1PRKD3MAP4K4RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295412-A1 | Indazole compounds useful as protein kinase inhibitors | Vertex Pharmaceuticals Incorporated (US) | 2011-03-16 | — | — | EP | disclosed |