Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 13/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.55 |
| ▸ | CLK2 | P49760 | 3/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.55 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.55 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.55 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.55 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.55 |
| ▸ | CDC7 | O00311 | 1/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20661235 | 0.88 | ROCK2 (0.67) | ROCK2ROCK1MAP4K4RPS6KB1CLK2 | |
| SCHEMBL1456516 | 0.86 | ROCK2 (0.53) | ROCK2ROCK1MAP4K4RPS6KB1CLK2 | |
| SCHEMBL1456959 | 0.86 | ROCK2 (0.58) | ROCK2ROCK1NPC1RAB9A | |
| SCHEMBL20661261 | 0.85 | ROCK2 (0.65) | ROCK2ROCK1MAP4K4RPS6KB1CLK2 | |
| SCHEMBL12824530 | 0.84 | ROCK2 (0.67) | ROCK2ROCK1MAP4K4RPS6KB1CLK2 | |
| SCHEMBL1457361 | 0.83 | ROCK2 (0.63) | ROCK2ROCK1MAP4K4RPS6KB1CLK2 | |
| SCHEMBL29099870 | 0.81 | ROCK2 (0.55) | ROCK2ROCK1MAP4K4RPS6KB1CLK2 | |
| SCHEMBL20661265 | 0.78 | ROCK2 (0.67) | ROCK2ROCK1MAP4K4RPS6KB1CLK2 | |
| SCHEMBL20661233 | 0.77 | ROCK2 (0.52) | ROCK2ROCK1MAP4K4RPS6KB1CLK2 | |
| SCHEMBL20661228 | 0.77 | ROCK2 (0.63) | ROCK2ROCK1MAP4K4RPS6KB1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1812973-B | Indazole compounds useful as protein kinase inhibitors | VERTEX PHARMA CO LTD | 2010-12-22 | — | — | CN | disclosed |
| US-7041687-B2 | Indazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-05-09 | — | — | US | disclosed |