Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.64 |
| ▸ | GCK | P35557 | 10/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | RARA | P10276 | 2/20 | 0.50 |
| ▸ | RARB | P10826 | 2/20 | 0.50 |
| ▸ | RARG | P13631 | 2/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5239506 | 0.85 | HCAR3 (0.68) | HCAR3GCKRAB9AMEN1KMT2A | |
| SCHEMBL9944094 | 0.84 | HCAR3 (0.58) | HCAR3GCKRAB9AMEN1KMT2A | |
| SCHEMBL27451977 | 0.84 | HCAR3 (0.69) | HCAR3GCKDEGS1RARARARB | |
| SCHEMBL1459281 | 0.82 | RAB9A (0.62) | HCAR3GCKRAB9AMEN1KMT2A | |
| SCHEMBL9944145 | 0.80 | MEN1 (0.67) | HCAR3GCKRAB9AMEN1KMT2A | |
| SCHEMBL2664544 | 0.79 | HCAR3 (1.00) | HCAR3GCKRAB9AMEN1KMT2A | |
| SCHEMBL5236720 | 0.78 | HCAR3 (0.66) | HCAR3GCKRAB9AMEN1KMT2A | |
| SCHEMBL5233651 | 0.78 | HCAR3 (0.57) | HCAR3GCKRAB9AMEN1KMT2A | |
| SCHEMBL31586306 | 0.78 | HCAR3 (0.57) | HCAR3GCKRAB9AMEN1KMT2A | |
| SCHEMBL5237722 | 0.78 | ALDH1A1 (0.58) | HCAR3GCKRAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011027106-A1 | THERAPEUTIC ARYL-AM I DO-ARYL COMPOUNDS AND THEIR USE | KING'S COLLEGE LONDON (GB) | 2011-03-10 | — | — | WO | disclosed |