Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.59 |
| ▸ | JAK1 | P23458 | 7/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.56 |
| ▸ | TTK | P33981 | 2/20 | 0.54 |
| ▸ | ULK1 | O75385 | 3/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12825311 | 0.87 | ROCK2 (0.53) | JAK2JAK1ROCK2TTKULK1 | |
| SCHEMBL12825316 | 0.87 | TTK (0.62) | ROCK2TTKCDC7PLK4CHEK1 | |
| SCHEMBL12825406 | 0.86 | TTK (0.66) | ROCK2TTKPLK4CHEK2AURKB | |
| SCHEMBL12826122 | 0.85 | HAO1 (0.52) | JAK2JAK1ROCK2TTKCDC7 | |
| SCHEMBL12826114 | 0.85 | TTK (0.60) | ROCK2TTKMAPK1ROCK1 | |
| SCHEMBL12825317 | 0.85 | TTK (0.57) | JAK2JAK1ROCK2TTKULK1 | |
| SCHEMBL12825512 | 0.83 | TTK (0.63) | ROCK2TTKPLK4CHEK2AURKB | |
| SCHEMBL12826071 | 0.83 | TTK (0.56) | ROCK2TTKCDC7PLK4CHEK1 | |
| SCHEMBL12826113 | 0.82 | TTK (0.62) | ROCK2TTKPLK4CHEK2MAPK8 | |
| SCHEMBL12826136 | 0.82 | TTK (0.50) | ROCK2TTKULK1CDC7PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295413-A1 | Indazole compounds useful as protein kinase inhibitors | Vertex Pharmaceuticals Incorporated (US) | 2011-03-16 | — | — | EP | disclosed |