Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.53 |
| ▸ | ULK1 | O75385 | 4/20 | 0.52 |
| ▸ | TTK | P33981 | 2/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12826136 | 0.92 | TTK (0.50) | ROCK2ULK1TTKROCK1MAPK1 | |
| SCHEMBL12825419 | 0.89 | TTK (0.46) | ROCK2ULK1TTKROCK1MAPK1 | |
| SCHEMBL12825520 | 0.87 | JAK2 (0.59) | ROCK2ULK1TTKROCK1MAPK1 | |
| SCHEMBL12826120 | 0.84 | ROCK2 (0.47) | ROCK2ULK1TTKROCK1MAPK1 | |
| SCHEMBL12825316 | 0.84 | TTK (0.62) | ROCK2TTKROCK1MAPK1CDK2 | |
| SCHEMBL12825525 | 0.83 | GSK3B (0.56) | ROCK2ULK1TTKROCK1MAPK1 | |
| SCHEMBL12825521 | 0.83 | TTK (0.49) | ROCK2ULK1TTKROCK1MAPK1 | |
| SCHEMBL12826119 | 0.82 | ROCK2 (0.48) | ROCK2ULK1TTKROCK1MAPK1 | |
| SCHEMBL12825406 | 0.82 | TTK (0.66) | ROCK2TTKPLK4CHEK2AURKB | |
| SCHEMBL12825317 | 0.81 | TTK (0.57) | ROCK2ULK1TTKROCK1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295413-A1 | Indazole compounds useful as protein kinase inhibitors | Vertex Pharmaceuticals Incorporated (US) | 2011-03-16 | — | — | EP | disclosed |