Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 5/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | PER2 | O15055 | 4/20 | 0.34 |
| ▸ | CRY1 | Q16526 | 4/20 | 0.34 |
| ▸ | CRY2 | Q49AN0 | 4/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12745370 | 0.86 | NR1I2 (0.45) | HDAC10HDAC6CFTRNR1I2PER2 | |
| SCHEMBL14845739 | 0.86 | CFTR (0.38) | HDAC10HDAC6CFTRNR1I2PER2 | |
| SCHEMBL20808191 | 0.72 | NR1I2 (0.34) | CFTRNR1I2PER2CRY1CRY2 | |
| SCHEMBL12827126 | 0.67 | CYP1A2 (0.40) | AKR1C3AKR1C2MEN1ALDH1A1MAPT | |
| SCHEMBL12745363 | 0.64 | NR1I2 (0.43) | HDAC10HDAC6CFTRNR1I2CACNA1B | |
| SCHEMBL28156097 | 0.61 | PTGS2 (0.47) | PTGS2ALDH1A1KMT2A | |
| SCHEMBL13365279 | 0.61 | ALDH1A1 (0.43) | MEN1ALDH1A1KMT2A | |
| SCHEMBL12745368 | 0.60 | NR1I2 (0.42) | HDAC10HDAC6CFTRNR1I2PER2 | |
| SCHEMBL12827228 | 0.57 | CFTR (0.37) | CFTRALDH1A1 | |
| SCHEMBL12827380 | 0.57 | AKR1C3 (0.42) | AKR1C3AKR1C2MEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110071206-A1 | Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-03-24 | — | — | US | disclosed |
| US-20110060024-A1 | Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-03-10 | — | — | US | disclosed |
| US-20100113555-A1 | Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071206-A1 | Modulators of ATP-Binding Cassette Transporters | CFTR, ABCB1, ABCC2 | HDAC10 2755/4885HDAC6 1646/4885CFTR 1/4885 |
| US-20100113555-A1 | Modulators of ATP-Binding Cassette Transporters | CFTR, ABCB1, ABCC2 | HDAC10 2755/4885HDAC6 1646/4885CFTR 1/4885 |
| US-20110060024-A1 | Modulators of ATP-Binding Cassette Transporters | CFTR, ABCB1, ABCC2 | HDAC10 2755/4885HDAC6 1646/4885CFTR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.