Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.52 |
| ▸ | ALDH1A3 | P47895 | 6/20 | 0.51 |
| ▸ | ALDH1A2 | O94788 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1420335 | 0.79 | ALDH1A3 (0.55) | DHODHALDH1A3ALDH1A2ALDH1A1NPC1 | |
| SCHEMBL5074229 | 0.76 | DHODH (0.67) | DHODHALDH1A3ALDH1A2ALDH1A1NPC1 | |
| SCHEMBL1420384 | 0.76 | NPC1 (0.65) | DHODHALDH1A3ALDH1A2ALDH1A1NPC1 | |
| SCHEMBL5251228 | 0.74 | DHODH (0.53) | DHODHALDH1A3ALDH1A2ALDH1A1NPC1 | |
| SCHEMBL11255204 | 0.73 | ALDH1A1 (0.59) | DHODHALDH1A3ALDH1A2ALDH1A1NPC1 | |
| SCHEMBL12753210 | 0.71 | DHODH (0.50) | DHODHALDH1A3ALDH1A2ALDH1A1NPC1 | |
| SCHEMBL12753201 | 0.70 | TMIGD3 (0.54) | DHODHALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL10211959 | 0.69 | DHODH (1.00) | DHODHALDH1A3ALDH1A2ALDH1A1NPC1 | |
| SCHEMBL973108 | 0.68 | ALDH1A3 (0.70) | DHODHALDH1A3ALDH1A2ALDH1A1NPC1 | |
| SCHEMBL13325903 | 0.68 | ALDH1A1 (0.94) | DHODHALDH1A3ALDH1A2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110077248-A1 | IMIDAZOPYRIDINE AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. | 2011-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077248-A1 | IMIDAZOPYRIDINE AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRT3, SIRT1, SIRT2 | DHODH 1141/4885ALDH1A3 2233/4885ALDH1A2 1871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.