Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12308580 | 0.83 | TSHR (0.60) | TSHRHPGDMAPK1ADORA3POLB | |
| SCHEMBL5776021 | 0.78 | MAPT (0.56) | TSHRHPGDMAPK1POLBALDH1A1 | |
| SCHEMBL12879083 | 0.73 | PTGS2 (0.40) | TSHRADORA3ALDH1A1MAPTGAA | |
| SCHEMBL5796644 | 0.72 | MAPT (0.48) | TSHRHPGDMAPK1ADORA3POLB | |
| SCHEMBL3939907 | 0.72 | ALDH1A1 (0.57) | TSHRADORA3POLBALDH1A1MAPT | |
| SCHEMBL6691068 | 0.70 | MAPT (0.61) | TSHRHPGDMAPK1POLBALDH1A1 | |
| SCHEMBL16448979 | 0.70 | TSHR (0.66) | TSHRHPGDMAPK1ADORA3POLB | |
| SCHEMBL11541403 | 0.69 | NPC1 (0.65) | TSHRPOLBALDH1A1MAPTGAA | |
| SCHEMBL2775568 | 0.68 | MAPT (0.74) | TSHRHPGDMAPK1POLBALDH1A1 | |
| SCHEMBL4948655 | 0.68 | HTT (0.58) | TSHRMAPK1POLBALOX15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2289504-A2 | SIRT1 modulators for manipulating cell/organism lifespan/stress response | President and Fellows of Harvard College (US) | 2011-03-02 | — | — | EP | disclosed |