Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.51 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.51 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12831402 | 0.85 | HDAC1 (0.61) | TP53MAPTHDAC1KIF11HDAC3 | |
| SCHEMBL9401140 | 0.83 | MAPKAPK2 (0.61) | TP53MAPTSMN1; SMN2MAPKAPK2KIF11 | |
| SCHEMBL1491493 | 0.81 | MAPKAPK2 (0.47) | TP53MAPTSMN1; SMN2HDAC1MAPKAPK2 | |
| SCHEMBL1491489 | 0.81 | MAPKAPK2 (0.47) | TP53MAPTSMN1; SMN2HDAC1MAPKAPK2 | |
| SCHEMBL28468254 | 0.81 | KIF11 (0.52) | TP53MAPTSMN1; SMN2MAPKAPK2KIF11 | |
| SCHEMBL12673048 | 0.81 | MAPKAPK2 (0.47) | TP53MAPTSMN1; SMN2HDAC1MAPKAPK2 | |
| SCHEMBL2707877 | 0.80 | MAPKAPK2 (0.62) | TP53MAPTSMN1; SMN2MAPKAPK2MAPKAPK5 | |
| SCHEMBL8243500 | 0.80 | HDAC1 (0.71) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL28468251 | 0.78 | MAPKAPK2 (0.52) | TP53MAPTSMN1; SMN2MAPKAPK2KIF11 | |
| SCHEMBL8025879 | 0.78 | MAPKAPK2 (0.59) | TP53MAPTSMN1; SMN2MAPKAPK2KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2301939-A1 | Enzyme inhibitors | Chroma Therapeutics Limited (GB) | 2011-03-30 | — | — | EP | disclosed |