Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29630294 | 0.86 | LMNA (0.61) | LMNAMEN1KMT2AMAPTGAA | |
| SCHEMBL12831409 | 0.85 | TP53 (0.51) | HDAC1HDAC6MAPTABCG2KIF11 | |
| SCHEMBL12831416 | 0.81 | HDAC1 (0.58) | HDAC1HDAC6LMNAMEN1KMT2A | |
| SCHEMBL18688577 | 0.80 | ADRA2C (0.53) | LMNAMEN1KMT2AMAPTGAA | |
| SCHEMBL1491430 | 0.79 | HDAC1 (0.54) | HDAC1HDAC6LMNAMEN1KMT2A | |
| SCHEMBL1877789 | 0.79 | HDAC1 (0.54) | HDAC1HDAC6LMNAMEN1KMT2A | |
| SCHEMBL1491428 | 0.79 | HDAC1 (0.54) | HDAC1HDAC6LMNAMEN1KMT2A | |
| SCHEMBL1491562 | 0.79 | HDAC1 (0.54) | HDAC1HDAC6LMNAMEN1KMT2A | |
| SCHEMBL14930036 | 0.79 | HDAC1 (0.51) | HDAC1HDAC6LMNAMEN1KMT2A | |
| SCHEMBL28465323 | 0.78 | LMNA (0.57) | LMNAMEN1KMT2AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2301939-A1 | Enzyme inhibitors | Chroma Therapeutics Limited (GB) | 2011-03-30 | — | — | EP | disclosed |