Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 2/20 | 0.39 |
| ▸ | CLK3 | P49761 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | TOP1 | P11387 | 2/20 | 0.39 |
| ▸ | TOP2A | P11388 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | GUSB | P08236 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12834285 | 0.88 | ALDH1A1 (0.40) | ALDH1A1HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL12834288 | 0.84 | RAB9A (0.45) | ALDH1A1HPGDSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL12834289 | 0.82 | LOXL2 (0.41) | ALDH1A1HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL14090255 | 0.82 | ALDH1A1 (0.59) | ALDH1A1HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL12834118 | 0.81 | KIT (0.42) | ALDH1A1HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL12834115 | 0.81 | KIT (0.39) | ALDH1A1HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL12834329 | 0.74 | KIT (0.36) | ALDH1A1HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL14089973 | 0.74 | LOXL2 (0.38) | ALDH1A1HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL18164007 | 0.73 | TGFB2 (0.52) | ALDH1A1HPGDSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL12833667 | 0.72 | ADORA2A (0.41) | ALDH1A1HPGDSMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298770-A1 | Heterocyclic compounds as TrkA modulators | ChemBridge Corporation (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2007056155-A1 | HETEROCYCLIC COMPOUNDS AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2007-05-18 | — | — | WO | disclosed |