Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | HKDC1 | Q2TB90 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | XBP1 | P17861 | 1/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.50 |
| ▸ | TTR | P02766 | 2/20 | 0.50 |
| ▸ | PTPRC | P08575 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | APAF1 | O14727 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12969793 | 0.95 | MEN1 (0.55) | KMT2AMEN1L3MBTL1SMN1; SMN2HKDC1 | |
| SCHEMBL7098579 | 0.91 | ALDH1A1 (0.62) | KMT2AMEN1L3MBTL1SMN1; SMN2HKDC1 | |
| SCHEMBL12761941 | 0.88 | ALDH1A1 (0.51) | KMT2AMEN1L3MBTL1SMN1; SMN2HKDC1 | |
| SCHEMBL12834559 | 0.87 | LMNA (0.49) | KMT2AMEN1L3MBTL1SMN1; SMN2HKDC1 | |
| SCHEMBL12834569 | 0.85 | ALDH1A1 (0.47) | KMT2AMEN1L3MBTL1SMN1; SMN2HKDC1 | |
| SCHEMBL12834565 | 0.85 | KMT2A (0.51) | KMT2AMEN1L3MBTL1SMN1; SMN2HKDC1 | |
| SCHEMBL12834576 | 0.85 | ALDH1A1 (0.58) | KMT2AMEN1L3MBTL1SMN1; SMN2HKDC1 | |
| SCHEMBL12834571 | 0.83 | SRD5A2 (0.47) | KMT2AMEN1L3MBTL1SMN1; SMN2HKDC1 | |
| SCHEMBL1507053 | 0.83 | CDC25B (0.52) | KMT2AMEN1L3MBTL1SMN1; SMN2HKDC1 | |
| SCHEMBL12834566 | 0.83 | MAPT (0.53) | KMT2AMEN1L3MBTL1SMN1; SMN2HKDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257515-B1 | 1,4-NAPHTHOQUINONE DERIVATIVES AND THERAPEUTIC USE THEREOF | CENTRE NAT RECH SCIENT (FR) | 2017-05-17 | — | — | EP | disclosed |
| US-9090549-B2 | 1,4-naphthoquinones derivatives and therapeutic use thereof | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2015-07-28 | — | — | US | disclosed |
| US-20110059972-A1 | 1,4-NAPHTHOQUINONES DERIVATIVES AND THERAPEUTIC USE THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059972-A1 | 1,4-NAPHTHOQUINONES DERIVATIVES AND THERAPEUTIC USE THEREOF | NQO1, NDUFV2, RECQL | KMT2A 2271/4885MEN1 2491/4885L3MBTL1 4372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.