Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 4/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22649171 | 0.81 | CYP1A2 (0.46) | CYP1A2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL28416384 | 0.75 | ALDH1A1 (0.47) | CYP1A2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL12834808 | 0.74 | CYP1A2 (0.50) | CYP1A2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL8873486 | 0.72 | CYP1A2 (0.48) | CYP1A2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL5796638 | 0.71 | CYP1A2 (0.47) | CYP1A2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL13134034 | 0.71 | CYP1A2 (0.47) | CYP1A2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL31526985 | 0.71 | CYP1A2 (0.47) | CYP1A2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL8129430 | 0.71 | CYP1A2 (0.47) | CYP1A2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL6520637 | 0.71 | CYP1A2 (0.47) | CYP1A2ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL2036237 | 0.71 | L3MBTL1 (0.54) | CYP1A2ALDH1A1MAPTKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011028864-A1 | JAK2 INHIBITORS AND THEIR USE FOR THE TREATMENT OF MYELOPROLIFERATIVE DISEASES AND CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-03-10 | — | — | WO | disclosed |