Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | PGR | P06401 | 2/20 | 0.53 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | DAO | P14920 | 5/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2522765 | 0.79 | LMNA (0.58) | LMNAPGRMAOBDAOBRD4 | |
| SCHEMBL7220155 | 0.79 | DAO (0.66) | LMNAPGRMAOBDAOBRD4 | |
| SCHEMBL29859942 | 0.79 | LMNA (0.58) | LMNAPGRMAOBDAOBRD4 | |
| SCHEMBL29914985 | 0.78 | PGR (0.69) | LMNAPGRMAOBDAOADORA3 | |
| SCHEMBL7220153 | 0.78 | LMNA (0.56) | LMNAPGRMAOBDAOBRD4 | |
| SCHEMBL29464110 | 0.78 | DAO (0.64) | LMNAPGRMAOBDAOBRD4 | |
| SCHEMBL3063232 | 0.78 | PGR (0.69) | LMNAPGRMAOBDAOADORA3 | |
| Hydrochloric Acid SCHEMBL19384637 | 0.78 | LMNA (0.56) | LMNAPGRMAOBDAOBRD4 | |
| SCHEMBL6770061 | 0.78 | DAO (0.64) | LMNAPGRMAOBDAOBRD4 | |
| SCHEMBL1519715 | 0.78 | LMNA (0.56) | LMNAPGRMAOBDAOBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897619-B2 | Heterocyclic modulators of PKB | AMGEN INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-20090275592-A1 | Heterocyclic modulators of PKB | AMGEN INC. (US) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275592-A1 | Heterocyclic modulators of PKB | MTOR, PDK1, EIF4EBP1 | LMNA 3419/4885PGR 741/4885MAOB 1562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.