SCHEMBL12839645

SCHEMBL12839645

COc1ccc(-c2cnc(NC(=O)Cc3ccc4ccccc4c3)c(CC(C)C)n2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RIOK2 Q9BVS4 6/20 0.51
MAPK10 P53779 4/20 0.51
GSK3A P49840 3/20 0.51
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
POLB P06746 1/20 0.46
PPARG P37231 1/20 0.46
NCOA2 Q15596 1/20 0.46
NCOA1 Q15788 1/20 0.46
CTDSP1 Q9GZU7 1/20 0.46
NCOA3 Q9Y6Q9 1/20 0.46
APP P05067 1/20 0.45
NPY5R Q15761 1/20 0.44
KDM4E B2RXH2 1/20 0.44
NPC1 O15118 1/20 0.44
ALDH1A1 P00352 1/20 0.44
ADRB2 P07550 1/20 0.44
HPGD P15428 1/20 0.44
RAB9A P51151 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12840375 0.91 RIOK2 (0.47) RIOK2MAPK10GSK3AMEN1KMT2A
SCHEMBL12838486 0.91 NLRP3 (0.45) RIOK2MAPK10GSK3AMEN1KMT2A
SCHEMBL12839646 0.91 ALDH1A1 (0.50) RIOK2MEN1KMT2AAPPKDM4E
SCHEMBL12838965 0.90 RIOK2 (0.53) RIOK2MAPK10GSK3AMEN1KMT2A
SCHEMBL12838532 0.88 KMT2A (0.52) MEN1KMT2APOLBAPPKDM4E
SCHEMBL12838484 0.88 RIOK2 (0.52) RIOK2MAPK10GSK3AMEN1KMT2A
SCHEMBL12840431 0.88 RIOK2 (0.52) RIOK2MAPK10GSK3AMEN1KMT2A
SCHEMBL12838567 0.88 MTOR (0.46) MAPK10MEN1KMT2AAPPKDM4E
SCHEMBL12838570 0.87 MEN1 (0.49) MEN1KMT2APOLBAPPALDH1A1
SCHEMBL12840052 0.85 MAPK10 (0.55) RIOK2MAPK10GSK3AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 RIOK2 4840/4885MAPK10 4844/4885GSK3A 4531/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.