SCHEMBL12840375

SCHEMBL12840375

CC(C)Cc1nc(-c2ccccc2)cnc1NC(=O)Cc1ccc2ccccc2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RIOK2 Q9BVS4 6/20 0.47
GSK3A P49840 3/20 0.47
MAPK10 P53779 3/20 0.47
MAPK8 P45983 1/20 0.47
HIPK1 Q86Z02 1/20 0.47
SNRK Q9NRH2 1/20 0.47
NR1H4 Q96RI1 1/20 0.46
HDAC3 O15379 1/20 0.44
HDAC4 P56524 1/20 0.44
HDAC1 Q13547 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
PIN1 Q13526 2/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
ELANE P08246 1/20 0.43
NLRP3 Q96P20 1/20 0.42
TPH1 P17752 1/20 0.42
ANO1 Q5XXA6 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12838486 0.93 NLRP3 (0.45) RIOK2GSK3AMAPK10MAPK8HIPK1
SCHEMBL12839645 0.91 RIOK2 (0.51) RIOK2GSK3AMAPK10MAPK8HIPK1
SCHEMBL12840374 0.89 TMIGD3 (0.49) MEN1KMT2A
SCHEMBL12840353 0.89 RIOK2 (0.54) RIOK2GSK3AMAPK10MAPK8HIPK1
SCHEMBL12839950 0.88 KMT2A (0.46) MEN1KMT2A
SCHEMBL12839947 0.87 RIOK2 (0.49) RIOK2GSK3AMAPK10MAPK8HIPK1
SCHEMBL12839948 0.87 NPC1 (0.43) L3MBTL1MEN1KMT2A
SCHEMBL12839940 0.87 CYP3A4 (0.45) MEN1KMT2A
SCHEMBL12839954 0.87 TMIGD3 (0.43) MEN1KMT2A
SCHEMBL12839952 0.87 KMT2A (0.45) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 RIOK2 4840/4885GSK3A 4531/4885MAPK10 4844/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.