SCHEMBL12840243

SCHEMBL12840243

CC(=O)Nc1nc2c(nc1C=C(C)C)-c1ccc(F)cc1CC2

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PTAFR P25105 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
DYRK1A Q13627 2/20 0.34
PDPK1 O15530 1/20 0.34
POLB P06746 1/20 0.34
CYP11B1 P15538 4/20 0.33
DHODH Q02127 3/20 0.33
ADORA3 P0DMS8 2/20 0.33
ADORA2A P29274 2/20 0.33
ADORA2B P29275 1/20 0.33
ADORA1 P30542 1/20 0.33
CYP19A1 P11511 4/20 0.32
CYP11B2 P19099 3/20 0.32
BAZ2B Q9UIF8 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
HTT P42858 1/20 0.32
TYMS P04818 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12840226 0.89 CYP1A2 (0.39) NPC1RAB9ACYP11B1DHODHCYP1A2
SCHEMBL12840183 0.88 TYR (0.38) PTAFRNPC1RAB9ADYRK1APOLB
SCHEMBL12840242 0.87 ALOX5 (0.39) PTAFRRAB9APOLBADORA1
SCHEMBL12839332 0.87 HSD17B10 (0.35) NPC1RAB9APOLBBAZ2BTYMS
SCHEMBL12840240 0.86 MEN1 (0.34) PTAFRADORA3ADORA2AADORA1
SCHEMBL12840239 0.85 TSHR (0.39) NPC1RAB9ADHODHHTT
SCHEMBL12838729 0.85 MAPT (0.47) NPC1RAB9ADYRK1AADORA3ADORA1
SCHEMBL12840224 0.85 SMN1; SMN2 (0.35) NPC1RAB9A
SCHEMBL12840573 0.85 ADORA3 (0.38) PTAFRNPC1RAB9APOLBCYP11B1
SCHEMBL12840525 0.84 POLB (0.49) NPC1RAB9APOLBCYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed
EP-1666488-B1 FLUORESCENT PROTEIN CHISSO CORP (JP) 2010-11-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 PTAFR 1993/4885NPC1 2936/4885RAB9A 2980/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.