SCHEMBL12840361

SCHEMBL12840361

Bc1ccc(CC(=O)Nc2ncc(-c3ccccc3)nc2CCC)cc1

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TMIGD3 P0DMS9 1/20 0.43
KMT2A Q03164 4/20 0.43
MEN1 O00255 3/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 1/20 0.43
WNT3A P56704 6/20 0.42
RORC P51449 1/20 0.41
ELOVL1 Q9BW60 1/20 0.41
ABL1 P00519 1/20 0.41
APP P05067 1/20 0.41
SLC6A2 P23975 1/20 0.40
SLC6A3 Q01959 1/20 0.40
LMNA P02545 1/20 0.40
PKM P14618 1/20 0.40
TSHR P16473 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12840363 0.90 KMT2A (0.46) TMIGD3KMT2AMEN1NPC1RAB9A
SCHEMBL12840371 0.89 TMIGD3 (0.43) TMIGD3KMT2AMEN1NPC1RAB9A
SCHEMBL12840376 0.89 KMT2A (0.46) TMIGD3KMT2AMEN1NPC1RAB9A
SCHEMBL12840364 0.89 KMT2A (0.45) TMIGD3KMT2AMEN1NPC1RAB9A
SCHEMBL12839947 0.86 RIOK2 (0.49) KMT2AMEN1WNT3A
SCHEMBL12838488 0.86 DEGS1 (0.47) TMIGD3KMT2AMEN1NPC1RAB9A
SCHEMBL13068291 0.85 TMIGD3 (0.43) TMIGD3KMT2AMEN1NPC1RAB9A
SCHEMBL13068038 0.85 MAPK14 (0.46) TMIGD3KMT2AMEN1NPC1RAB9A
SCHEMBL12840377 0.85 CACNA1H (0.41) TMIGD3KMT2AMEN1NPC1RAB9A
SCHEMBL12839097 0.84 ROCK1 (0.44) TMIGD3KMT2AMEN1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 TMIGD3 1782/4885KMT2A 4653/4885MEN1 3926/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.