SCHEMBL12840377

SCHEMBL12840377

CCCc1nc(-c2ccccc2)cnc1NC(=O)Cc1ccc(F)c(F)c1

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CACNA1H O95180 8/20 0.41
WNT3A P56704 4/20 0.41
KCNQ2 O43526 1/20 0.40
CACNA1G O43497 1/20 0.40
CACNA1I Q9P0X4 1/20 0.40
TMIGD3 P0DMS9 1/20 0.39
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
RAB9A P51151 2/20 0.39
ABL1 P00519 1/20 0.39
GSK3A P49840 1/20 0.39
GSK3B P49841 1/20 0.39
NPC1 O15118 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13067793 0.92 CACNA1H (0.42) CACNA1HWNT3AKCNQ2CACNA1GCACNA1I
SCHEMBL12839010 0.92 WNT3A (0.42) CACNA1HWNT3AKCNQ2CACNA1GCACNA1I
SCHEMBL12839106 0.91 CACNA1H (0.41) CACNA1HWNT3ACACNA1GCACNA1IMEN1
SCHEMBL12838994 0.91 TMIGD3 (0.42) CACNA1HWNT3AKCNQ2CACNA1GCACNA1I
SCHEMBL12839071 0.90 CACNA1H (0.40) CACNA1HWNT3ACACNA1GCACNA1IMEN1
SCHEMBL12840364 0.89 KMT2A (0.45) WNT3ATMIGD3MEN1KMT2ARAB9A
SCHEMBL12839632 0.89 KMT2A (0.52) WNT3AMEN1KMT2ARAB9ANPC1
SCHEMBL12839947 0.88 RIOK2 (0.49) WNT3AMEN1KMT2AGSK3A
SCHEMBL12839927 0.88 TMIGD3 (0.43) CACNA1HWNT3AKCNQ2CACNA1GCACNA1I
SCHEMBL12840376 0.87 KMT2A (0.46) WNT3ATMIGD3MEN1KMT2ARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 CACNA1H 110/4885WNT3A 510/4885KCNQ2 1883/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.