SCHEMBL12840399

SCHEMBL12840399

O=C(Cc1ccc(Cl)cc1)Nc1ncc(-c2ccc(O)cc2)nc1CCc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.46
MEN1 O00255 3/20 0.46
NPY5R Q15761 2/20 0.45
DEGS1 O15121 1/20 0.44
CACNA1G O43497 1/20 0.43
CACNA1H O95180 1/20 0.43
CACNA1I Q9P0X4 1/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
ADAMTS5 Q9UNA0 1/20 0.42
MAPK1 P28482 1/20 0.42
TMIGD3 P0DMS9 1/20 0.41
MTOR P42345 1/20 0.41
NLRP3 Q96P20 1/20 0.41
GLS O94925 1/20 0.41
ATR Q13535 1/20 0.41
TSHR P16473 1/20 0.40
CYP2C8 P10632 1/20 0.40
CYP2C9 P11712 1/20 0.40
HCAR2 Q8TDS4 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2508250 0.95 DEGS1 (0.48) KMT2AMEN1DEGS1NPC1RAB9A
SCHEMBL12839000 0.94 KMT2A (0.47) KMT2AMEN1NPY5RCACNA1GCACNA1H
SCHEMBL12838875 0.94 DEGS1 (0.49) KMT2AMEN1DEGS1NPC1RAB9A
SCHEMBL12840496 0.91 KMT2A (0.46) KMT2AMEN1NPY5RCACNA1GCACNA1H
SCHEMBL12839147 0.91 NPY5R (0.44) KMT2AMEN1NPY5RCACNA1GCACNA1H
SCHEMBL12838882 0.91 DEGS1 (0.45) KMT2AMEN1NPY5RDEGS1CACNA1G
SCHEMBL12840388 0.90 DEGS1 (0.44) KMT2AMEN1DEGS1NPC1RAB9A
SCHEMBL12840400 0.90 DEGS1 (0.44) KMT2AMEN1DEGS1NPC1RAB9A
SCHEMBL12840398 0.90 KMT2A (0.45) KMT2AMEN1DEGS1NPC1RAB9A
SCHEMBL12839144 0.90 KMT2A (0.45) KMT2AMEN1DEGS1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 KMT2A 4653/4885MEN1 3926/4885NPY5R 3856/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.