SCHEMBL12840496

SCHEMBL12840496

Nc1ccc(-c2cnc(NC(=O)Cc3ccc(Cl)cc3)c(CCc3ccccc3)n2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.46
MEN1 O00255 3/20 0.46
NPY5R Q15761 2/20 0.44
ATR Q13535 2/20 0.44
GLS O94925 1/20 0.41
TMIGD3 P0DMS9 1/20 0.41
CACNA1G O43497 1/20 0.41
CACNA1H O95180 1/20 0.41
CACNA1I Q9P0X4 1/20 0.41
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
HIF1A Q16665 1/20 0.40
TSHR P16473 1/20 0.40
ADAMTS5 Q9UNA0 1/20 0.39
ALDH1A1 P00352 1/20 0.39
POLB P06746 1/20 0.39
HPGD P15428 1/20 0.39
GHSR Q92847 1/20 0.39
CSNK1D P48730 1/20 0.39
KDM4E B2RXH2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12839214 0.94 TMIGD3 (0.45) KMT2AMEN1ATRGLSTMIGD3
SCHEMBL12839000 0.93 KMT2A (0.47) KMT2AMEN1NPY5RTMIGD3CACNA1G
SCHEMBL12839659 0.91 ATR (0.45) KMT2AMEN1NPY5RATRGLS
SCHEMBL12840399 0.91 KMT2A (0.46) KMT2AMEN1NPY5RATRGLS
SCHEMBL12839147 0.90 NPY5R (0.44) KMT2AMEN1NPY5RATRTMIGD3
SCHEMBL12840498 0.90 GLS (0.41) KMT2AMEN1ATRGLSTMIGD3
SCHEMBL12840483 0.90 GLS (0.41) KMT2AMEN1ATRGLSTMIGD3
SCHEMBL13068290 0.88 RORC (0.43) KMT2AMEN1ATRNPC1RAB9A
SCHEMBL12838524 0.88 APP (0.49) KMT2AMEN1GLSCACNA1GCACNA1H
SCHEMBL12839244 0.87 RIOK2 (0.44) KMT2AMEN1NPY5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110070656-A1 Fluorescent Proteins JNC CORPORATION (JP) 2011-03-24 US disclosed
EP-1666488-B1 FLUORESCENT PROTEIN CHISSO CORP (JP) 2010-11-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110070656-A1 Fluorescent Proteins CACYBP, CHLSN, LCP2 KMT2A 4653/4885MEN1 3926/4885NPY5R 3856/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.