Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 15/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 15/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 15/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 15/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 15/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 13/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.56 |
| ▸ | TP53 | P04637 | 6/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 12/20 | 0.55 |
| ▸ | MEN1 | O00255 | 10/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.55 |
| ▸ | LMNA | P02545 | 8/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | GLA | P06280 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12845351 | 0.93 | HTT (0.58) | HTTUSP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8265749 | 0.93 | PAK4 (0.55) | HTTUSP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12845502 | 0.86 | KMT2A (0.56) | HTTPTGS1PTGS2MEN1KMT2A | |
| SCHEMBL12845365 | 0.82 | HTR2A (0.61) | USP2CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL8043495 | 0.81 | USP2 (0.49) | HTTUSP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12845353 | 0.81 | GAK (0.53) | HTTMAPK1PTGS2MEN1KMT2A | |
| SCHEMBL12845437 | 0.80 | FADS1 (0.51) | PTGS1PTGS2KMT2AMAPT | |
| SCHEMBL12845326 | 0.80 | HTR1A (0.53) | HTTCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL12845354 | 0.80 | POLB (0.59) | USP2CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL7006163 | 0.77 | DRD2 (0.73) | HTTPTGS2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404683-B2 | Inhibitors of the interaction between MDM2 and P53 | JANSSEN PHARMACEUTICAL N.V. (BE) | 2013-03-26 | — | — | US | disclosed |
| US-20110053937-A1 | Inhibitors of the Interaction Between MDM2 and P53 | LACRAMPE JEAN FERNAND ARMAND | 2011-03-03 | — | — | US | disclosed |
| US-7834016-B2 | Inhibitors of the interaction between MDM2 and p53 | JANSSEN PHARMACEUTICA NV (BE) | 2010-11-16 | — | — | US | disclosed |
| US-7834016-B2 | Inhibitors of the interaction between MDM2 and p53 | JANSSEN PHARMACEUTICA NV (BE) | 2010-11-16 | — | — | US | disclosed |
| US-20080039472-A1 | Inhibitors of the Interaction Between Mdm2 and P53 | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-14 | — | — | US | disclosed |
| US-20080039472-A1 | Inhibitors of the Interaction Between Mdm2 and P53 | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053937-A1 | Inhibitors of the Interaction Between MDM2 and P53 | TP53, MDM2, TP53BP1 | HTT 439/4885USP2 1488/4885CYP1A2 2773/4885 |
| US-20080039472-A1 | Inhibitors of the Interaction Between Mdm2 and P53 | TP53, MDM2, TP53BP1 | HTT 439/4885USP2 1488/4885CYP1A2 2773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.