Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8274438 | 0.82 | ENPP1 (0.62) | ENPP1MAPK1ALDH1A1ATMKDM4E | |
| SCHEMBL8272559 | 0.78 | ENPP1 (0.69) | ENPP1ALDH1A1ATMKDM4ETSHR | |
| SCHEMBL12786024 | 0.78 | ENPP1 (0.50) | ENPP1MAPK1ALDH1A1ATMTSHR | |
| Hydrochloric Acid SCHEMBL30088883 | 0.77 | ENPP1 (0.67) | ENPP1ALDH1A1ATMKDM4ETSHR | |
| SCHEMBL29688141 | 0.77 | ENPP1 (0.53) | ENPP1ALDH1A1ATMKDM4ETSHR | |
| SCHEMBL831675 | 0.77 | ENPP1 (0.53) | ENPP1ALDH1A1ATMKDM4ETSHR | |
| SCHEMBL13720327 | 0.76 | ENPP1 (0.55) | ENPP1MAPK1ALDH1A1ATMKDM4E | |
| SCHEMBL13720770 | 0.76 | HTR3A (0.53) | ENPP1MAPK1ALDH1A1ATMTSHR | |
| SCHEMBL19951504 | 0.76 | TSHR (0.63) | ENPP1ALDH1A1ATMTSHRMEN1 | |
| SCHEMBL13721430 | 0.76 | PARP1 (0.53) | ENPP1MAPK1ALDH1A1ATMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150072972-A1 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-03-12 | — | — | US | disclosed |
| US-8946221-B2 | Phthalazine derivatives as PARP inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2015-02-03 | — | — | US | disclosed |
| US-20110065684-A1 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS | MEVELLEC LAURENCE ANNE | 2011-03-17 | — | — | US | disclosed |
| US-7803795-B2 | Phthalazine derivatives as parp inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-09-28 | — | — | US | disclosed |
| US-7803795-B2 | Phthalazine derivatives as parp inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-09-28 | — | — | US | disclosed |
| US-20080139568-A1 | Phthalazine Derivatives as Parp Inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-06-12 | — | — | US | disclosed |
| US-20080139568-A1 | Phthalazine Derivatives as Parp Inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150072972-A1 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS | PARP1, PARP2, PARP11 | ENPP1 1708/4885MAPK1 2149/4885ALDH1A1 551/4885 |
| US-20080139568-A1 | Phthalazine Derivatives as Parp Inhibitors | PARP1, PARP2, PARP11 | ENPP1 1728/4885MAPK1 2090/4885ALDH1A1 494/4885 |
| US-20110065684-A1 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS | PARP1, PARP2, PARP11 | ENPP1 1708/4885MAPK1 2149/4885ALDH1A1 551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.