Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 4/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL831675 | 1.00 | ENPP1 (0.53) | ENPP1HTR2CPARP1ATMKDM4E | |
| SCHEMBL13720327 | 0.83 | ENPP1 (0.55) | ENPP1PARP1ATMKDM4ENPSR1 | |
| SCHEMBL13721430 | 0.83 | PARP1 (0.53) | ENPP1PARP1ATMKDM4EMAPT | |
| SCHEMBL13720770 | 0.83 | HTR3A (0.53) | ENPP1PARP1ATMTSHRALDH1A1 | |
| SCHEMBL19951504 | 0.83 | TSHR (0.63) | ENPP1PARP1ATMMAPTNPSR1 | |
| SCHEMBL30417899 | 0.83 | TSHR (0.63) | ENPP1PARP1ATMMAPTNPSR1 | |
| SCHEMBL8274438 | 0.80 | ENPP1 (0.62) | ENPP1ATMKDM4ENPSR1HTR6 | |
| SCHEMBL29468202 | 0.80 | KDM4E (0.54) | HTR2CPARP1KDM4EMAPTHTR6 | |
| SCHEMBL1132419 | 0.80 | KDM4E (0.54) | HTR2CPARP1KDM4EMAPTHTR6 | |
| Hydrochloric Acid SCHEMBL5767318 | 0.79 | KDM4E (0.56) | HTR2CPARP1KDM4EMAPTHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4028009-A1 | TREATMENT OF HR DEFICIENT CANCER | The Francis Crick Institute Limited (GB) | 2022-07-20 | — | — | EP | disclosed |