Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 3/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.53 |
| ▸ | HTR3B | O95264 | 1/20 | 0.53 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.53 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.53 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30417899 | 0.84 | TSHR (0.63) | ENPP1ATMPARP1ALDH1A1LMNA | |
| SCHEMBL19951504 | 0.84 | TSHR (0.63) | ENPP1ATMPARP1ALDH1A1LMNA | |
| SCHEMBL831675 | 0.83 | ENPP1 (0.53) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL29688141 | 0.83 | ENPP1 (0.53) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL13721430 | 0.81 | PARP1 (0.53) | ENPP1ATMPARP1MAPK1ALDH1A1 | |
| SCHEMBL13720327 | 0.81 | ENPP1 (0.55) | ENPP1ATMPARP1MAPK1ALDH1A1 | |
| SCHEMBL1545498 | 0.81 | CDC7 (0.53) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL19951493 | 0.80 | LMNA (0.51) | ENPP1PARP1MAPK1ALDH1A1LMNA | |
| SCHEMBL30418223 | 0.80 | LMNA (0.51) | ENPP1PARP1MAPK1ALDH1A1LMNA | |
| SCHEMBL13720391 | 0.80 | ALDH1A1 (0.60) | ENPP1PARP1ALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859549-B2 | Potassium channel modulators | ABBVIE, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| WO-2012158399-A1 | CONDENSED 2 - CARBAMOYLPYRIDAZINONES AS POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-11-22 | — | — | WO | disclosed |
| US-20120289500-A1 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289500-A1 | POTASSIUM CHANNEL MODULATORS | KCNQ1, KCNQ2, KCNJ2 | HTR3A 1216/4885HTR3E 1886/4885HTR3B 883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.