SCHEMBL12846320

SCHEMBL12846320

CCCCOCC(N)c1ccc(Cl)cc1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SCN4A P35499 5/20 0.50
SLC2A1 P11166 1/20 0.46
ADRB2 P07550 1/20 0.42
TACR1 P25103 1/20 0.41
SLC6A2 P23975 4/20 0.38
SLC6A3 Q01959 4/20 0.38
SLC6A4 P31645 3/20 0.38
LMNA P02545 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
KDM4E B2RXH2 1/20 0.37
THRB P10828 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
IDO1 P14902 1/20 0.36
TDO2 P48775 1/20 0.36
AOC3 Q16853 1/20 0.36
HTT P42858 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C19 P33261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5664431 0.82 SCN4A (0.52) SCN4ASLC2A1TACR1
SCHEMBL5462262 0.80 SCN4A (0.53) SCN4AADRB2TACR1SLC6A2SLC6A3
SCHEMBL5460859 0.80 SCN4A (0.53) SCN4AADRB2TACR1SLC6A2SLC6A3
SCHEMBL4985324 0.78 SLC2A1 (0.51) SCN4ASLC2A1ADRB2SLC6A2SLC6A3
SCHEMBL8438898 0.77 SLC2A1 (0.58) SCN4ASLC2A1ADRB2SLC6A2SLC6A3
SCHEMBL12846321 0.75 KCNH2 (0.41) SCN4ASLC2A1LMNASMN1; SMN2KDM4E
SCHEMBL12846089 0.75 KCNH2 (0.40) KDM4ETHRBTDP1CYP1A2
SCHEMBL5720835 0.75 L3MBTL1 (0.48) SLC2A1LMNASMN1; SMN2TDP1CYP1A2
SCHEMBL12846137 0.75 KCNH2 (0.41) SCN4ASLC2A1LMNASMN1; SMN2KDM4E
SCHEMBL12846088 0.75 KCNH2 (0.41) SCN4ASLC2A1LMNASMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7897601-B2 Cannabinoid receptor modulators INTERVET, INC. (US) 2011-03-01 US disclosed
US-20070197628-A1 Cannabinoid receptor modulators INTERVET INTERNATIONAL B.V. (NL) 2007-08-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070197628-A1 Cannabinoid receptor modulators CNR1, CNR2, GPR18 SCN4A 853/4885SLC2A1 2533/4885ADRB2 73/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.