SCHEMBL128480

SCHEMBL128480

Cc1nn2c(C)cc(N)nc2c1N

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 1/20 0.42
KDM4E B2RXH2 4/20 0.35
HTR6 P50406 1/20 0.35
TSHR P16473 3/20 0.34
HSD17B10 Q99714 2/20 0.34
MAPT P10636 8/20 0.34
MAPK1 P28482 1/20 0.34
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
ALDH1A1 P00352 3/20 0.33
NOS3 P29474 1/20 0.33
NOS1 P29475 1/20 0.33
NOS2 P35228 1/20 0.33
SMN1; SMN2 Q16637 3/20 0.33
PTGS2 P35354 1/20 0.33
NPC1 O15118 1/20 0.33
HCRTR1 O43613 1/20 0.33
LMNA P02545 1/20 0.33
TP53 P04637 1/20 0.33
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL38666647 0.85 PIK3CG (0.50) PIK3CGKDM4EHTR6TSHRHSD17B10
SCHEMBL7459734 0.80 ALDH1A1 (0.35) PIK3CGKDM4ETSHRMAPTMAPK1
SCHEMBL7460863 0.75 HTR6 (0.33) KDM4EHTR6MEN1KMT2ANPC1
SCHEMBL126427 0.74 KDM4E (0.58) PIK3CGKDM4EHTR6TSHRHSD17B10
SCHEMBL7465690 0.69 MEN1 (0.44) KDM4ETSHRMAPTMAPK1MEN1
SCHEMBL5132511 0.68 KDM4E (0.45) KDM4EHTR6TSHRHSD17B10MAPT
SCHEMBL128209 0.68 ENPP1 (0.45) KDM4EHTR6MAPTMEN1KMT2A
Hydrochloric Acid SCHEMBL7827431 0.67 ENPP1 (0.44) KDM4EHTR6MAPTMEN1KMT2A
SCHEMBL31329986 0.67 HPGD (0.36) PIK3CGKDM4ETSHRHSD17B10MAPT
SCHEMBL7456702 0.67 MAPT (0.49) PIK3CGKDM4EHTR6TSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2182 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1443890-B1 OXIDATION COLOURING AGENT BASED ON BICYCLIC DEVELOPER COMPONENTS HENKEL AG & CO KGAA (DE) 2010-01-13 EP claimed
EP-1352636-B1 Oxidation dyeing composition for keratin fibers comprising 2-chloro-6-methyl-3-aminophenol and an oxidation base, and dyeing method OREAL (FR) 2009-04-22 EP claimed
EP-1405627-B1 Antipenetrating hair pretreatment composition based on polyethelenoxide polymer(s) and process using said composition for limiting skin penetration by colourants OREAL (FR) 2008-04-30 EP claimed
WO-2007071686-A1 COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE, AN OXIDATION BASE AND A PARTICULAR COUPLER L'ORÉAL (FR) 2007-06-28 WO claimed
WO-2007071688-A1 COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE, A PARTICULAR OXIDATION BASE AND A COUPLER L'ORÉAL (FR) 2007-06-28 WO claimed
US-7189267-B2 Oxyethylenated based hair pre-treatment anti-penetration composition and method using such a composition for limiting the penetration of dyes into the skin L'OREAL (FR) 2007-03-13 US claimed
US-7077871-B2 Coloring composition for keratin fibres comprising a system limiting the transcutaneous passage of an oxidation dye L'OREAL (FR) 2006-07-18 US claimed
EP-1210931-B1 Keratinic fibres dyeing composition OREAL (FR) 2006-04-05 EP claimed
EP-1621185-A1 Hair dyeing composition comprising an elastomeric film-forming polymer and an oxidation dye precursor L'OREAL (FR) 2006-02-01 EP claimed
US-20060000033-A1 Dyeing composition comprising at least one elastomeric film-forming polymer and at least one oxidation dye precursor L'OREAL S.A. (FR) 2006-01-05 US claimed
EP-0966951-A1 Dye composition containing 1,8-bis-(2,5-diaminophenoxy)-3,5-dioxaoctane, an additional oxidation base and a coupler, and dyeing process L'OREAL (FR) 1999-12-29 EP claimed
EP-0966252-A1 OXIDATION DYEING COMPOSITION FOR KERATIN FIBRES COMPRISING 2-CHLORO 6 METHYL 3-AMINOPHENOL AND AN OXIDATION BASE, AND DYEING METHOD L'OREAL (FR) 1999-12-29 EP claimed
WO-1999066891-A1 OXIDATION DYEING COMPOSITION FOR KERATINOUS FIBRES AND DYEING METHOD USING SAME L'OREAL (FR) 1999-12-29 WO claimed
WO-1999066892-A1 OXIDATION DYEING COMPOSITION FOR KERATINOUS FIBRES AND DYEING METHOD USING SAME L'OREAL (FR) 1999-12-29 WO claimed
WO-1999048465-A1 OXIDATION DYEING COMPOSITION FOR KERATINOUS FIBRES CONTAINING A 3-AMINOPYRIDINE AZO DERIVATIVE AND DYEING METHOD USING SAID COMPOSITION L'OREAL (FR) 1999-09-30 WO claimed
WO-1999036039-A1 KERATINOUS FIBRE OXIDATION DYEING COMPOSITION CONTAINING A LACCASE AND DYEING METHOD USING SAME L'OREAL (FR) 1999-07-22 WO claimed
WO-1999011230-A1 OXIDATION DYEING COMPOSITION FOR KERATIN FIBRES COMPRISING 2-CHLORO 6 METHYL 3-AMINOPHENOL AND AN OXIDATION BASE, AND DYEING METHOD L'OREAL (FR) 1999-03-11 WO claimed
WO-1998055083-A1 KERATIN FIBRE OXIDATION DYEING COMPOSITION AND DYEING METHOD USING SAME L'OREAL (FR) 1998-12-10 WO claimed
EP-0847271-A1 PYRAZOLO-(1,5-a)-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND HAIR DYES CONTAINING THESE L'OREAL (FR) 1998-06-17 EP claimed
WO-1997049378-A1 PYRAZOLO-(1,5-a)-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND HAIR DYES CONTAINING THESE L'OREAL (FR) 1997-12-31 WO claimed