Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30015754 | 0.83 | KMT2A (0.47) | TP53ALDH1A1HSD17B10MAPK1GAA | |
| SCHEMBL28923516 | 0.83 | KMT2A (0.47) | TP53ALDH1A1HSD17B10MAPK1GAA | |
| SCHEMBL7466727 | 0.82 | L3MBTL1 (0.53) | TP53ALDH1A1MAPK1GAAUSP2 | |
| SCHEMBL17434273 | 0.80 | ALDH1A1 (0.60) | ALDH1A1HSD17B10MAPK1GAAUSP2 | |
| SCHEMBL17434276 | 0.80 | ALDH1A1 (0.60) | ALDH1A1HSD17B10MAPK1GAAUSP2 | |
| SCHEMBL5670842 | 0.80 | ALDH1A1 (0.65) | TP53ALDH1A1HSD17B10MAPK1GAA | |
| SCHEMBL26121632 | 0.78 | IDO1 (0.44) | TP53ALDH1A1HSD17B10MAPK1GAA | |
| SCHEMBL26121628 | 0.78 | IDO1 (0.44) | TP53ALDH1A1HSD17B10MAPK1GAA | |
| SCHEMBL26121623 | 0.78 | IDO1 (0.44) | TP53ALDH1A1HSD17B10MAPK1GAA | |
| Hydrochloric Acid SCHEMBL30556925 | 0.77 | IDO1 (0.43) | TP53ALDH1A1HSD17B10MAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2686306-B1 | BENZO[B][1,4]OXAZIN DERIVATIVES AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN ATLANTIS HOLDINGS SA (CH) | 2017-01-04 | — | — | EP | disclosed |
| EP-2686306-B1 | BENZO[B][1,4]OXAZIN DERIVATIVES AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN ATLANTIS HOLDINGS SA (CH) | 2017-01-04 | — | — | EP | disclosed |
| US-9464063-B2 | Benzo [B] [1,4] oxazin derivatives as calcium sensing receptor modulators | LUPIN ATLANTIS HOLDINGS SA (CH) | 2016-10-11 | — | — | US | disclosed |
| US-9464063-B2 | Benzo [B] [1,4] oxazin derivatives as calcium sensing receptor modulators | LUPIN ATLANTIS HOLDINGS SA (CH) | 2016-10-11 | — | — | US | disclosed |
| US-9464063-B2 | Benzo [B] [1,4] oxazin derivatives as calcium sensing receptor modulators | LUPIN ATLANTIS HOLDINGS SA (CH) | 2016-10-11 | — | — | US | disclosed |
| US-20140018358-A1 | BENZO [B] [1,4] OXAZIN DERIVATIVES AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2014-01-16 | — | — | US | disclosed |
| US-20140018358-A1 | BENZO [B] [1,4] OXAZIN DERIVATIVES AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2014-01-16 | — | — | US | disclosed |
| US-20140018358-A1 | BENZO [B] [1,4] OXAZIN DERIVATIVES AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2014-01-16 | — | — | US | disclosed |
| WO-2012127388-A1 | BENZO [B] [1, 4] OXAZIN DERIVATIVES AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2012-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140018358-A1 | BENZO [B] [1,4] OXAZIN DERIVATIVES AS CALCIUM SENSING RECEPTOR MODULATORS | CASR, RYR1, RYR2 | TP53 4351/4885ALDH1A1 2490/4885HSD17B10 2051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.