Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 7/20 | 0.59 |
| ▸ | GRIN2A | Q12879 | 7/20 | 0.59 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.59 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.59 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.59 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.59 |
| ▸ | PRCP | P42785 | 2/20 | 0.59 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12852018 | 0.99 | GRIN1 (0.57) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL12851995 | 0.96 | OPRM1 (0.55) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL12852065 | 0.92 | GRIN1 (0.53) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL12852089 | 0.90 | GRIN1 (0.53) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL12851999 | 0.87 | OPRM1 (0.53) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL12852000 | 0.87 | OPRM1 (0.53) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL12852054 | 0.86 | OPRM1 (0.51) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL28282384 | 0.81 | GRIN1 (0.88) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL12852088 | 0.80 | OPRM1 (0.50) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B | |
| SCHEMBL19634059 | 0.79 | GRIN1 (0.84) | GRIN1GRIN2AGRIN2BGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278319-B2 | Substituted spiroamine compounds | GRUENENTHAL GMBH (DE) | 2012-10-02 | — | — | US | disclosed |
| US-20100113417-A1 | Substituted Spiroamine Compounds | GRUENENTHAL GMBH (DE) | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113417-A1 | Substituted Spiroamine Compounds | BDKRB1, BDKRB2, REN | GRIN1 574/4885GRIN2A 801/4885GRIN2B 513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.