Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 11/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 11/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1285341 | 0.93 | MAPT (0.38) | MAPTTHRBTP53 | |
| SCHEMBL1285753 | 0.85 | KCNH2 (0.35) | MTNR1AMTNR1BMAPTTHRBDRD2 | |
| SCHEMBL3426737 | 0.77 | MTNR1A (0.54) | MTNR1AMTNR1B | |
| SCHEMBL1696503 | 0.71 | MTNR1A (0.50) | MTNR1AMTNR1B | |
| SCHEMBL1285668 | 0.70 | MTNR1A (0.66) | MTNR1AMTNR1BDRD2HTR2ADRD3 | |
| SCHEMBL1285447 | 0.70 | MTNR1A (0.38) | MTNR1AMTNR1BMAPTTP53 | |
| SCHEMBL3432115 | 0.69 | MTNR1A (0.56) | MTNR1AMTNR1BMAPT | |
| SCHEMBL1286234 | 0.66 | DPP4 (0.43) | MTNR1AMTNR1B | |
| SCHEMBL1696502 | 0.65 | MTNR1A (0.51) | MTNR1AMTNR1B | |
| SCHEMBL1285161 | 0.64 | DPP4 (0.42) | MTNR1AMTNR1BDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443108-A1 | 1-(2-ALKYL-2,3-DIHYDRO-BENZOFURAN-4-YL)-PYRROLIDIN-3-YLAMINE ACYL COMPOUNDS | Ferrer Internacional, S.A. (ES) | 2012-04-25 | — | — | EP | disclosed |
| US-20120088809-A1 | 1-(2-ALKYL-2,3-DIHYDRO-BENZOFURAN-4-YL)-PYRROLIDIN-3-YLAMINE ACYL COMPOUNDS | FERRER INTERNACIONAL, S.A. (ES) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088809-A1 | 1-(2-ALKYL-2,3-DIHYDRO-BENZOFURAN-4-YL)-PYRROLIDIN-3-YLAMINE ACYL COMPOUNDS | MTNR1A, MTNR1B, TPH2 | MTNR1A 1/4885MTNR1B 2/4885MAPT 603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.