Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 1.00 |
| ▸ | ABL1 | P00519 | 8/20 | 1.00 |
| ▸ | ABL2 | P42684 | 8/20 | 1.00 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.62 |
| ▸ | PRKDC | P78527 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 12/20 | 0.54 |
| ▸ | CDK1 | P06493 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | TEK | Q02763 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8820310 | 0.79 | EGFR (0.78) | EGFRABL1ABL2SRCCDK1 | |
| SCHEMBL407936 | 0.77 | PIK3CD (1.00) | EGFRABL1ABL2PIK3CDPIK3CA | |
| SCHEMBL8819225 | 0.75 | EGFR (0.72) | EGFRABL1ABL2SRCKDR | |
| SCHEMBL2074335 | 0.73 | KDR (0.76) | EGFRABL1ABL2PIK3CDPIK3CA | |
| SCHEMBL7005327 | 0.72 | TEK (0.76) | EGFRABL1ABL2SRCKDR | |
| SCHEMBL27378709 | 0.71 | PIK3CD (0.63) | EGFRABL1ABL2PIK3CDPIK3CA | |
| SCHEMBL7057974 | 0.70 | PIK3CD (0.73) | EGFRABL1ABL2PIK3CDPIK3CA | |
| SCHEMBL7834175 | 0.70 | SRC (0.71) | EGFRABL1ABL2PIK3CDPIK3CA | |
| SCHEMBL7845870 | 0.69 | SRC (1.00) | EGFRABL1ABL2SRCCDK1 | |
| Dimethylamine SCHEMBL7834177 | 0.69 | SRC (0.71) | EGFRABL1ABL2PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1364212-B1 | THREE HYBRID ASSAY SYSTEM | GPC BIOTECH AG (DE) | 2011-02-02 | — | — | EP | disclosed |
| EP-1975620-A2 | Three hybrid assay system | GPC Biotech AG (DE) | 2008-10-01 | — | — | EP | disclosed |