Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.72 |
| ▸ | KDR | P35968 | 9/20 | 0.64 |
| ▸ | TEK | Q02763 | 8/20 | 0.64 |
| ▸ | SRC | P12931 | 6/20 | 0.64 |
| ▸ | LCK | P06239 | 5/20 | 0.64 |
| ▸ | ABL1 | P00519 | 6/20 | 0.62 |
| ▸ | ABL2 | P42684 | 6/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8820310 | 0.96 | EGFR (0.78) | EGFRKDRTEKSRCLCK | |
| SCHEMBL2074335 | 0.83 | KDR (0.76) | EGFRKDRTEKSRCLCK | |
| SCHEMBL2073299 | 0.81 | KDR (0.76) | EGFRKDRTEKSRCLCK | |
| SCHEMBL7005359 | 0.78 | TEK (1.00) | EGFRKDRTEKSRCLCK | |
| SCHEMBL29552512 | 0.78 | TEK (1.00) | EGFRKDRTEKSRCLCK | |
| SCHEMBL27555108 | 0.78 | TEK (0.74) | EGFRKDRTEKSRCLCK | |
| SCHEMBL7848142 | 0.77 | SRC (1.00) | EGFRKDRTEKSRCLCK | |
| SCHEMBL12856370 | 0.75 | EGFR (1.00) | EGFRKDRTEKSRCABL1 | |
| SCHEMBL24459029 | 0.75 | TEK (0.77) | EGFRKDRTEKSRCLCK | |
| SCHEMBL16769997 | 0.75 | TEK (0.78) | KDRTEKSRCLCKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997032879-A1 | 7-ALKYL-PYRROLO[2,3-d]PYRIMIDINES | NOVARTIS AG (CH) | 1997-09-12 | — | — | WO | disclosed |