Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13299617 | 0.79 | NUDT1 (0.68) | NUDT1KDM4EKMT2ACHRM3PDE4A | |
| SCHEMBL9217636 | 0.79 | NUDT1 (0.68) | NUDT1KDM4EMAPTKMT2AHRH4 | |
| SCHEMBL5806017 | 0.78 | NUDT1 (0.66) | NUDT1KDM4EKMT2ACHRM3PDE4A | |
| SCHEMBL9182925 | 0.78 | NUDT1 (1.00) | NUDT1HRH4CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL10878260 | 0.78 | MEN1 (0.43) | NUDT1KDM4EMAPTRXFP1KMT2A | |
| SCHEMBL10830610 | 0.77 | HRH4 (0.53) | NUDT1KDM4EMAPTRXFP1KMT2A | |
| SCHEMBL18019807 | 0.77 | NUDT1 (1.00) | NUDT1HRH4CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL17979734 | 0.75 | NUDT1 (0.93) | NUDT1HRH4CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL16211680 | 0.75 | KMT2A (0.74) | NUDT1KDM4EMAPTRXFP1KMT2A | |
| SCHEMBL10650101 | 0.74 | KMT2A (0.63) | KDM4EMAPTRXFP1KMT2ACRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140303137-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2014-10-09 | — | — | US | disclosed |
| US-20110046104-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-02-24 | — | — | US | disclosed |
| US-20100137305-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046104-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | AURKC, AURKA, AURKB | NUDT1 301/4885KDM4E 754/4885MAPT 954/4885 |
| US-20140303137-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | AURKC, AURKA, AURKB | NUDT1 301/4885KDM4E 754/4885MAPT 954/4885 |
| US-20100137305-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | AURKC, AURKA, AURKB | NUDT1 301/4885KDM4E 754/4885MAPT 954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.