Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | PKM | P14618 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL828560 | 0.85 | TP53 (0.51) | SMN1; SMN2RAB9ANPC1PKMLMNA | |
| SCHEMBL10276435 | 0.79 | TP53 (0.60) | SMN1; SMN2RAB9ANPC1PKMLMNA | |
| SCHEMBL12695291 | 0.75 | ALDH1A1 (0.45) | SMN1; SMN2RAB9ANPC1PKMALDH1A1 | |
| SCHEMBL10260439 | 0.74 | MEN1 (0.56) | SMN1; SMN2RAB9ANPC1LMNAALDH1A1 | |
| SCHEMBL8240613 | 0.74 | RAB9A (0.59) | SMN1; SMN2RAB9ANPC1PKMLMNA | |
| SCHEMBL2035487 | 0.74 | LMNA (0.68) | SMN1; SMN2RAB9ANPC1PKMLMNA | |
| SCHEMBL13922914 | 0.74 | RAB9A (0.59) | SMN1; SMN2RAB9ANPC1PKMLMNA | |
| SCHEMBL829141 | 0.73 | RAB9A (0.62) | SMN1; SMN2RAB9ANPC1PKMLMNA | |
| SCHEMBL21348778 | 0.73 | NPC1 (0.53) | SMN1; SMN2RAB9ANPC1PKMLMNA | |
| SCHEMBL15354529 | 0.73 | RIOK2 (0.50) | PKMKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2284169-A1 | Derivatives of 4-piperazin-1-yl-4-benzo[b]thiophene suitable for the treatment of CNS disorders | Otsuka Pharmaceutical Co., Limited (JP) | 2011-02-16 | — | — | EP | disclosed |