Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.56 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.56 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.52 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.39 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL28493880 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GPR84 | |
| Maleic Acid SCHEMBL29100284 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GPR84 | |
| Maleic Acid SCHEMBL29100274 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GPR84 | |
| Fumaric Acid SCHEMBL28614026 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GPR84 | |
| Maleic Acid SCHEMBL10940457 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GPR84 | |
| Fumaric Acid SCHEMBL29100293 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GPR84 | |
| Maleic Acid SCHEMBL29100315 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GPR84 | |
| Fumaric Acid SCHEMBL28921786 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GPR84 | |
| Maleic Acid SCHEMBL29100314 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GPR84 | |
| Fumaric Acid SCHEMBL28628467 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8960247-B2 | Pneumatic tire | BRIDGESTONE CORPORATION (JP) | 2015-02-24 | — | — | US | disclosed |
| EP-2116396-B1 | PNEUMATIC TIRE | BRIDGESTONE CORP (JP) | 2014-04-23 | — | — | EP | disclosed |
| EP-2105461-B1 | RUBBER COMPOSITION AND PNEUMATIC TIRE USING THE SAME | BRIDGESTONE CORP (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-8110625-B2 | Rubber composition | BRIDGESTONE CORPORATION (JP) | 2012-02-07 | — | — | US | disclosed |
| EP-2223958-B1 | Rubber composition | BRIDGESTONE CORP (JP) | 2011-12-28 | — | — | EP | disclosed |
| EP-1816156-B1 | RUBBER COMPOSITION AND PNEUMATIC TIRE USING THE SAME | BRIDGESTONE CORP (JP) | 2011-09-07 | — | — | EP | disclosed |
| US-20100298488-A1 | RUBBER COMPOSITION | BRIDGESTONE CORPORATION (JP) | 2010-11-25 | — | — | US | disclosed |
| US-7799856-B2 | Rubber composition | BRIDGESTONE CORPORATION (JP) | 2010-09-21 | — | — | US | disclosed |
| EP-2226354-A1 | Rubber composition | Bridgestone Corporation (JP) | 2010-09-08 | — | — | EP | disclosed |
| EP-2223958-A1 | Rubber composition | Bridgestone Corporation (JP) | 2010-09-01 | — | — | EP | disclosed |
| US-20100036006-A1 | RUBBER COMPOSITION AND PNEUMATIC TIRE USING THE SAME | BRIDGESTONE CORPORATION (JP) | 2010-02-11 | — | — | US | disclosed |
| US-20100024937-A1 | PNEUMATIC TIRE | BRIDGESTONE CORPORATION (JP) | 2010-02-04 | — | — | US | disclosed |
| EP-2116396-A1 | PNEUMATIC TIRE | Bridgestone Corporation (JP) | 2009-11-11 | — | — | EP | disclosed |
| EP-2105461-A1 | RUBBER COMPOSITION AND PNEUMATIC TIRE USING THE SAME | Bridgestone Corporation (JP) | 2009-09-30 | — | — | EP | disclosed |
| US-20080035260-A1 | Rubber Composition and Pneumatic Tire Using the Same | BRIDGESTONE CORPORATION (JP) | 2008-02-14 | — | — | US | disclosed |
| EP-1816156-A1 | RUBBER COMPOSITION AND PNEUMATIC TIRE USING THE SAME | Bridgestone Corporation (JP) | 2007-08-08 | — | — | EP | disclosed |
| US-20040249032-A1 | Rubber composition | BRIDGESTONE CORPORATION (JP) | 2004-12-09 | — | — | US | disclosed |
| EP-1435375-A1 | RUBBER COMPOSITION | Bridgestone Corporation (JP) | 2004-07-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298488-A1 | RUBBER COMPOSITION | RAD50, RAD54L, VCL | MEN1 3075/4885KMT2A 2721/4885TSHR 3760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.