Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
| ▸ | GLI1 | P08151 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL27784481 | 0.84 | SCN4A (0.39) | SCN4AGLI1DPP4MEN1KMT2A | |
| SCHEMBL200642 | 0.82 | ALDH1A1 (0.37) | — | |
| SCHEMBL200643 | 0.82 | ALDH1A1 (0.37) | — | |
| SCHEMBL555055 | 0.81 | ALDH1A1 (0.40) | — | |
| SCHEMBL158232 | 0.81 | ALDH1A1 (0.40) | — | |
| Hydrochloric Acid SCHEMBL5204062 | 0.81 | ALDH1A1 (0.36) | — | |
| Proline SCHEMBL26181011 | 0.79 | MEN1 (0.42) | SCN4ADPP4MEN1KMT2ADPP8 | |
| Proline SCHEMBL28198776 | 0.79 | SCN4A (0.46) | SCN4AGLI1DPP4MEN1KMT2A | |
| Proline SCHEMBL27493189 | 0.79 | SCN4A (0.46) | SCN4AGLI1DPP4MEN1KMT2A | |
| Proline SCHEMBL1740645 | 0.77 | TP53 (0.42) | SCN4ADPP4MEN1KMT2ADPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120087969-A1 | Mu-Conotoxin Peptides and Use Thereof as a Local Anesthetic | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120087969-A1 | Mu-Conotoxin Peptides and Use Thereof as a Local Anesthetic | VIP, OPRL1, OPRM1 | SCN4A 123/4885GLI1 4089/4885DPP4 2473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.