Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Iodobenzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 3/20 | 0.46 |
| ▸ | CES1 | P23141 | 3/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodobenzene SCHEMBL29444116 | 1.00 | TPMT (0.48) | TPMTCES2CES1NAPRTHSD17B10 | |
| Iodobenzene SCHEMBL28221906 | 1.00 | TPMT (0.48) | TPMTCES2CES1NAPRTHSD17B10 | |
| Iodobenzene SCHEMBL318185 | 1.00 | TPMT (0.48) | TPMTCES2CES1NAPRTHSD17B10 | |
| Iodobenzene SCHEMBL20943249 | 1.00 | TPMT (0.48) | TPMTCES2CES1NAPRTHSD17B10 | |
| Iodobenzene SCHEMBL27878636 | 1.00 | TPMT (0.48) | TPMTCES2CES1NAPRTHSD17B10 | |
| Iodobenzene SCHEMBL28152784 | 0.97 | TPMT (0.46) | TPMTCES2CES1NAPRTHSD17B10 | |
| Iodobenzene SCHEMBL28174332 | 0.97 | TPMT (0.46) | TPMTCES2CES1NAPRTHSD17B10 | |
| Iodobenzene SCHEMBL28706495 | 0.97 | TPMT (0.46) | TPMTCES2CES1NAPRTHSD17B10 | |
| Iodobenzene SCHEMBL28458279 | 0.95 | TPMT (0.44) | TPMTCES2CES1NAPRTHSD17B10 | |
| Iodobenzene SCHEMBL27618758 | 0.94 | TPMT (0.48) | TPMTCES2CES1NAPRTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1990 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122080274-A | Preparation method of functionalized polyolefin | — | 2026-05-26 | — | — | CN | claimed |
| CN-122059864-A | Azido-containing seleno-ether compound, seleno-oxide, preparation methods and application | 福建师范大学 | 2026-05-19 | — | — | CN | claimed |
| CN-121086336-B | Method for degrading phenolic resin into functionalized oligomer | 北京化工大学 | 2026-05-15 | — | — | CN | claimed |
| US-12617952-B1 | Self-ameliorate-fissure-responsive pod system for alkyd-polyester aircraft runway paint | UNIVERSITY OF TABUK (SA) | 2026-05-05 | — | — | US | claimed |
| US-20260078129-A1 | JAK INHIBITOR AND PREPARATION METHOD THEREFOR | FELICAMED BIOTECHNOLOGY CO LTD (CN) | 2026-03-19 | — | — | US | claimed |
| US-12509463-B2 | JAK inhibitor and preparation method therefor | FELICAMED BIOTECHNOLOGY CO., LTD. (CN) | 2025-12-30 | — | — | US | claimed |
| US-12365678-B2 | Pharmaceutical process for the preparation of 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((R)-S-methylsulfonimidoyl) cyclopropyl]pyrimidin-2-yl}-1H-pyrrolo[2,3-b] pyridine and intermediates | ASTRAZENECA AB (SE) | 2025-07-22 | — | — | US | claimed |
| CN-120192272-A | Preparation method of benzoxazole intermediate | 帕潘纳(北京)科技有限公司 | 2025-06-24 | — | — | CN | claimed |
| CN-120192308-A | 1, 3-Dithiane substituted pyran derivative and preparation method and application thereof | 兰州大学 | 2025-06-24 | — | — | CN | claimed |
| CN-120136684-A | Synthesis method of p-tert-butylcalix [4] arene bridged ketone derivative | 天津医科大学 | 2025-06-13 | — | — | CN | claimed |
| CN-110818663-A | Synthetic method of nabacacine homolog | 肇庆市万维新材料科技有限公司 | 2020-02-21 | — | — | CN | claimed |
| CN-110759843-A | Preparation and application of fluorine azide substituted quaternary heterocyclic compound | 东北师范大学 | 2020-02-07 | — | — | CN | claimed |
| CN-107474001-B | synthetic method of α -diacetoxymethyl substituted nitrogen heterocyclic compounds | 河南师范大学 | 2020-01-31 | — | — | CN | claimed |
| CN-110684072-A | Preparation method of panax japonicus saponin IVa butyl ester | 华东理工大学 | 2020-01-14 | — | — | CN | claimed |
| CN-108976174-A | A kind of 3- trifluoromethyl the research of quinoxalinone derivatives preparation method | 河北工业大学 | 2018-12-11 | — | — | CN | claimed |
| CN-104169292-A | Method for preparing fully protection heparin pentasaccharide and intermediate thereof | ZHEJIANG HISUN PHARM CO LTD | 2014-11-26 | — | — | CN | claimed |
| EP-2283159-B1 | SYNTHESIS OF (+) CORTISTATIN A AND RELATED COMPOUNDS | SCRIPPS RESEARCH INST (US) | 2013-10-09 | — | — | EP | claimed |
| CN-102153580-A | Benzotriazole or naphthotriazole derivative and synthesis method thereof | UNIV SHANGHAI | 2011-08-17 | — | — | CN | claimed |
| US-20110060140-A1 | SYNTHESIS OF (+) CORTISTATIN A AND RELATED COMPOUNDS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-03-10 | — | — | US | claimed |
| CN-101691378-A | Benzo or naphtha isoxazolidine derivatives and synthesis method thereof | UNIV SHANGHAI | 2010-04-07 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12365678-B2 | Pharmaceutical process for the preparation of 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((R)-S-methylsulfonimidoyl) cyclopropyl]pyrimidin-2-yl}-1H-pyrrolo[2,3-b] pyridine and intermediates | TPMT, CYP3A7, HTR7 | TPMT 1/4885CES2 3645/4885CES1 2663/4885 |
| US-12617952-B1 | Self-ameliorate-fissure-responsive pod system for alkyd-polyester aircraft runway paint | PARG, PLOD3, PARN | TPMT 4725/4885CES2 4188/4885CES1 4733/4885 |
| US-20110060140-A1 | SYNTHESIS OF (+) CORTISTATIN A AND RELATED COMPOUNDS | CTTN, CIAPIN1, PACSIN2 | TPMT 4747/4885CES2 1850/4885CES1 1875/4885 |
| US-20260078129-A1 | JAK INHIBITOR AND PREPARATION METHOD THEREFOR | JAK1, JAK2, JAK3 | TPMT 178/4885CES2 2881/4885CES1 284/4885 |
| US-12509463-B2 | JAK inhibitor and preparation method therefor | JAK1, JAK2, JAK3 | TPMT 340/4885CES2 2698/4885CES1 310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.