Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Firibastat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPEP known ✓ | Q07075 | 1/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Firibastat SCHEMBL1694944 | 1.00 | S1PR2 (0.39) | S1PR2S1PR1S1PR3LMNASLC6A6 | |
| Firibastat SCHEMBL17151264 | 1.00 | S1PR2 (0.39) | S1PR2S1PR1S1PR3LMNASLC6A6 | |
| Firibastat SCHEMBL17240388 | 1.00 | S1PR2 (0.39) | S1PR2S1PR1S1PR3LMNASLC6A6 | |
| Firibastat SCHEMBL1290915 | 0.98 | S1PR2 (0.38) | S1PR2S1PR1S1PR3LMNASLC6A6 | |
| Firibastat SCHEMBL4606353 | 0.98 | S1PR2 (0.38) | S1PR2S1PR1S1PR3LMNASLC6A6 | |
| SCHEMBL15237131 | 0.90 | S1PR2 (0.41) | S1PR2S1PR1S1PR3LMNASLC6A6 | |
| SCHEMBL17148360 | 0.89 | S1PR2 (0.37) | S1PR2S1PR1S1PR3LMNASLC6A6 | |
| SCHEMBL24042972 | 0.87 | APP (0.36) | S1PR2S1PR1S1PR3LMNASLC6A6 | |
| SCHEMBL30541823 | 0.87 | PMP22 (0.41) | S1PR2S1PR1S1PR3BLMENPEP | |
| SCHEMBL29291937 | 0.87 | PMP22 (0.41) | S1PR2S1PR1S1PR3BLMENPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150284325-A1 | CRYSTALLINE PHASE OF (3S.3S') 4,4'-DISULFANEDIYLBIS(3-AMINOBUTANE 1-SULFONIC ACID) WITH L-LYSINE | QUANTUM GENOMICS (FR) | 2015-10-08 | — | — | US | claimed |
| EP-1525188-B1 | NOVEL DERIVATIVES OF 4,4'-DITHIOBIS-(3-AMINOBUTANE-1-SULPHONATES) AND COMPOSITIONS CONTAINING SAME | INST NAT SANTE RECH MED (FR) | 2008-07-09 | — | — | EP | claimed |
| EP-1183287-B1 | ORGANIC SEMICONDUCTORS BASED ON STATISTICAL COPOLYMERS | QINETIQ LTD (GB) | 2005-01-26 | — | — | EP | claimed |
| EP-1183287-A1 | ORGANIC SEMICONDUCTORS BASED ON STATISTICAL COPOLYMERS | QinetiQ Limited (GB) | 2002-03-06 | — | — | EP | claimed |
| WO-2000069931-A1 | ORGANIC SEMICONDUCTORS BASED ON STATISTICAL COPOLYMERS | QINETIQ LIMITED (GB) | 2000-11-23 | — | — | WO | claimed |
| CN-115605199-A | Pharmaceutical combination comprising a cerebral aminopeptidase inhibitor, a diuretic and a systemic renin-angiotensin system blocker | 量子基因组公司（FR） | 2023-01-13 | — | — | CN | disclosed |
| EP-3395796-B1 | A CRYSTALLINE TRIHYDRATE FORM OF (3S,3S') 4,4'-DISULFANEDIYLBIS (3-AMINOBUTANE 1-SULFONIC ACID) | QUANTUM GENOMICS (FR) | 2021-11-24 | — | — | EP | disclosed |
| EP-2793878-B1 | COMBINATION OF (3S,3S') 4,4'-DISULFANEDIYLBIS(3-AMINOBUTANE 1-SULFONIC ACID) AND A SECOND ANTIHYPERTENSIVE AGENT | QUANTUM GENOMICS (FR) | 2017-02-01 | — | — | EP | disclosed |
| US-9278921-B2 | Crystalline phase of (3S.3S′) 4,4′-disulfanediylbis(3-aminobutane 1-sulfonic acid) with L-lysine | QUANTUM GENOMICS (FR) | 2016-03-08 | — | — | US | disclosed |
| US-9187418-B2 | Method for the preparation of (3S, 3S′) 4,4′-disulfanediylbis (3-aminobutane 1-sulfonic acid) | QUANTUM GENOMICS (FR) | 2015-11-17 | — | — | US | disclosed |
| EP-2909169-A1 | CRYSTALLINE PHASE OF (3S.3S') 4,4'-DISULFANEDIYLBIS(3-AMINOBUTANE 1 -SULFONIC ACID) WITH L-LYSINE | Quantum Genomics (FR) | 2015-08-26 | — | — | EP | disclosed |
| CN-104220062-A | Combination of (3S,3S ') 4, 4' -disulfanediylbis (3-aminobutane 1-sulfonic acid) and a second antihypertensive agent | QUANTUM GENOMICS | 2014-12-17 | — | — | CN | disclosed |
| WO-2005014535-A1 | NOVEL DERIVATIVES OF 4,4'-DITHIOBIS-(3-AMINOBUTANE-1-SULFONATES) AND COMPOSITIONS COMPRISING THE SAME | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2005-02-17 | — | — | WO | disclosed |
| EP-1183287-B1 | ORGANIC SEMICONDUCTORS BASED ON STATISTICAL COPOLYMERS | QINETIQ LTD (GB) | 2005-01-26 | — | — | EP | disclosed |
| WO-2004007441-A3 | NOVEL DERIVATIVES OF 4,4'-DITHIOBIS-(3-AMINOBUTANE-1-SULPHONATES) AND COMPOSITIONS CONTAINING SAME | INST NAT SANTE RECH MED (FR) | 2004-04-08 | — | — | WO | disclosed |
| WO-2004007441-A2 | NOVEL DERIVATIVES OF 4,4'-DITHIOBIS-(3-AMINOBUTANE-1-SULPHONATES) AND COMPOSITIONS CONTAINING SAME | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2004-01-22 | — | — | WO | disclosed |
| WO-2004007441-A2 | NOVEL DERIVATIVES OF 4,4'-DITHIOBIS-(3-AMINOBUTANE-1-SULPHONATES) AND COMPOSITIONS CONTAINING SAME | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2004-01-22 | — | — | WO | disclosed |
| US-6642332-B1 | N-heterocyclic hole and electron transporting groups linked to vinyl group of addition polymers; electronic work function; charge carrier mobility; controlled emmission; storage stability; film-forming; light emitting diode | QINETIQ LIMITED (GB) | 2003-11-04 | — | — | US | disclosed |
| EP-1183287-A1 | ORGANIC SEMICONDUCTORS BASED ON STATISTICAL COPOLYMERS | QinetiQ Limited (GB) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069931-A1 | ORGANIC SEMICONDUCTORS BASED ON STATISTICAL COPOLYMERS | QINETIQ LIMITED (GB) | 2000-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284325-A1 | CRYSTALLINE PHASE OF (3S.3S') 4,4'-DISULFANEDIYLBIS(3-AMINOBUTANE 1-SULFONIC ACID) WITH L-LYSINE | SBDS, ACMSD, ADSL | ENPEP 632/4885S1PR2 3307/4885S1PR1 2762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.