Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 6/20 | 0.34 |
| ▸ | MAOA | P21397 | 3/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4404026 | 1.00 | MAPK1 (0.40) | MAPK1SMN1; SMN2ALDH1A1MAOBMAOA | |
| SCHEMBL21153824 | 1.00 | MAPK1 (0.40) | MAPK1SMN1; SMN2ALDH1A1MAOBMAOA | |
| SCHEMBL2116916 | 1.00 | MAPK1 (0.40) | MAPK1SMN1; SMN2ALDH1A1MAOBMAOA | |
| SCHEMBL6023016 | 0.84 | CXCR3 (0.35) | MAPK1SMN1; SMN2ALDH1A1MAOBMAOA | |
| SCHEMBL2478791 | 0.82 | SLC6A2 (0.40) | SMN1; SMN2MAOBMAOAKCNH2HSD11B1 | |
| SCHEMBL2481548 | 0.82 | MAOB (0.38) | MAPK1ALDH1A1MAOBMAOAMEN1 | |
| SCHEMBL2477286 | 0.82 | MAOB (0.38) | MAPK1ALDH1A1MAOBMAOAMEN1 | |
| SCHEMBL2481090 | 0.82 | MAOB (0.39) | MAOBMAOAMEN1KMT2AHSD11B1 | |
| SCHEMBL2482801 | 0.82 | MAOB (0.39) | MAOBMAOAMEN1KMT2AHSD11B1 | |
| SCHEMBL10992027 | 0.82 | SLC6A2 (0.40) | SMN1; SMN2MAOBMAOAKCNH2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014009767-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF 1-ARYL 2-AMINOMETHYL CYCLOPROPANE CARBOXYAMIDE (Z) DERIVATIVES, THEIR ISOMERS AND SALTS | MICRO LABS LIMITED (IN) | 2014-01-16 | — | — | WO | claimed |
| EP-1767522-B1 | METHOD FOR PRODUCING (Z)-1-PHENYL-1-DIETHYLAMINOCARBONYL-2-HYDROXYMETHYL CYCLOPROPANE | SUMITOMO CHEMICAL CO (JP) | 2013-01-16 | — | — | EP | claimed |
| WO-2012046247-A2 | PROCESS FOR THE PREPARATION OF (±M1R(S), 2SRR)L-2-(AMINOMETHYL)-N,N-DIETHYL-L-PHENYLCYCLOPROPANE CARBOXAMIDE HYDROCHLORIDE | MSN LABORATORIES LIMITED (IN) | 2012-04-12 | — | — | WO | claimed |
| WO-2011158249-A1 | PROCESS FOR PREPARATION OF MILNACIPRAN INTERMEDIATE AND ITS USE IN PREPARATION OF PURE MILNACIPRAN | GLENMARK GENERICS LIMITED (IN) | 2011-12-22 | — | — | WO | claimed |
| US-7943785-B2 | Process for producing (Z)-1-phenyl-1-(N,N-diethylaminocarbonyl)-2- phthalimidomethylcyclopropane | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-05-17 | — | — | US | claimed |
| EP-1845084-B1 | PROCESS FOR PRODUCING (Z)-1-PHENYL-1-(N,N-DIETHYLAMINOCARBONYL)IDOMETHYLCYCLOPROPANE | SUMITOMO CHEMICAL CO (JP) | 2011-04-20 | — | — | EP | claimed |
| US-20090292127-A1 | Process for Producing (Z)-1-Phenyl-1-(N,N-Diethylaminocarbonyl)-2-Phthalimidomethylcyclopropane | SUMITOMO CHEMICAL COMPANY, LIMITED | 2009-11-26 | — | — | US | claimed |
| US-7432396-B2 | Process for producing (Z)-1-phenyl-1-diethylaminocarbonyl-2-hydroxymethylcyclopropane | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2008-10-07 | — | — | US | claimed |
| US-20080064885-A1 | Process for Producing 2-Oxo-1-Phenyl-3-Oxabicyclo[3.1.0]Hexane | SUMITOMO CHEMICAL COMPANY, LIMITED | 2008-03-13 | — | — | US | claimed |
| US-20070249864-A1 | Process for Producing (Z)-1-Phenyl-1-Diethylaminocarbonyl-2-Hydroxymethylcyclopropane | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2007-10-25 | — | — | US | claimed |
| EP-1845084-A1 | PROCESS FOR PRODUCING (Z)-1-PHENYL-1-(N,N-DIETHYLAMINOCARBONYL)IDOMETHYLCYCLOPROPANE | Sumitomo Chemical Company, Limited (JP) | 2007-10-17 | — | — | EP | claimed |
| EP-1767522-A1 | METHOD FOR PRODUCING (Z)-1-PHENYL-1-DIETHYLAMINOCARBONYL-2-HYDROXYMETHYL CYCLOPROPANE | Sumitomo Chemical Company, Limited (JP) | 2007-03-28 | — | — | EP | claimed |
| EP-1757597-A1 | METHOD FOR PRODUCING 2-OXO-1-PHENYL-3-OXABICYCLO¬3.1.0|HEXANE | Sumitomo Chemical Company, Limited (JP) | 2007-02-28 | — | — | EP | claimed |
| US-20180251431-A1 | 1,3-SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL FOR REDUCTION OF VERY LONG CHAIN FATTY ACID LEVELS | VERTEX PHARMACEUTICALS INCORPORATED | 2018-09-06 | — | — | US | disclosed |
| WO-2018107056-A1 | 1,3-SUBSTITUED PYRAZOLE COMPOUNDS USEFUL FOR REDUCTION OF VERY LONG CHAIN FATTY ACIC LEVELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-06-14 | — | — | WO | disclosed |
| US-9595734-B2 | Non-aqueous liquid electrolyte for secondary battery and secondary battery | FUJIFILM CORPORATION (JP) | 2017-03-14 | — | — | US | disclosed |
| US-5034541-A | Method of preparing 1-phenyl-1-diethylaminocarbonyl-2-phthalimidomethyl-cyclopropane-z | PIERRE FABRE MEDICAMENT (FR) | 1991-07-23 | — | — | US | disclosed |
| US-5034541-A | Method of preparing 1-phenyl-1-diethylaminocarbonyl-2-phthalimidomethyl-cyclopropane-z | PIERRE FABRE MEDICAMENT (FR) | 1991-07-23 | — | — | US | disclosed |
| EP-0377381-A1 | Process for the preparation of 1-phenyl-1-diethyl amino-carbonyl-2-phthalimide methyl cyclopropane Z | PIERRE FABRE MEDICAMENT (FR) | 1990-07-11 | — | — | EP | disclosed |
| US-4507318-A | 1-Aryl 2-aminomethyl cyclopropane carboxylates (Z) as drugs in the treatment of pain | PIERRE FABRE S.A. (FR) | 1985-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090292127-A1 | Process for Producing (Z)-1-Phenyl-1-(N,N-Diethylaminocarbonyl)-2-Phthalimidomethylcyclopropane | BPNT1, CPN1, PNN | MAPK1 842/4885SMN1; SMN2 1783/4885ALDH1A1 667/4885 |
| US-20180251431-A1 | 1,3-SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL FOR REDUCTION OF VERY LONG CHAIN FATTY ACID LEVELS | HSD17B4, CPT1A, ADH1A | MAPK1 2428/4885SMN1; SMN2 1064/4885ALDH1A1 69/4885 |
| US-20080064885-A1 | Process for Producing 2-Oxo-1-Phenyl-3-Oxabicyclo[3.1.0]Hexane | HPD, PAH, HAAO | MAPK1 630/4885SMN1; SMN2 3013/4885ALDH1A1 174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.