Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 8/20 | 0.35 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709226 | 0.84 | SCN9A (1.00) | SCN9AFFAR4 | |
| SCHEMBL10072357 | 0.79 | SCN9A (0.88) | SCN9AMAPTHTTSMN1; SMN2NPSR1 | |
| SCHEMBL1286795 | 0.79 | SCN9A (1.00) | SCN9AMAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL1709219 | 0.71 | SCN9A (0.74) | SCN9ALMNAPOLB | |
| SCHEMBL1709230 | 0.71 | SCN9A (0.61) | SCN9AHTT | |
| SCHEMBL1286845 | 0.68 | SCN9A (0.66) | SCN9ALMNAPOLB | |
| SCHEMBL1709228 | 0.68 | SCN9A (0.69) | SCN9ALMNASMN1; SMN2NPSR1HTR1A | |
| SCHEMBL10072037 | 0.68 | SCN9A (0.62) | SCN9AMAPTPOLB | |
| SCHEMBL10072167 | 0.67 | SCN9A (0.61) | SCN9APOLB | |
| SCHEMBL1286821 | 0.67 | SCN9A (0.61) | SCN9AMAPTPOLBSMN1; SMN2FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | claimed |
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |