Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.62 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10072167 | 0.89 | SCN9A (0.61) | SCN9ADRD4POLBKMT2AMITF | |
| SCHEMBL1709219 | 0.88 | SCN9A (0.74) | SCN9ADRD4POLBKMT2AMITF | |
| SCHEMBL1286845 | 0.87 | SCN9A (0.66) | SCN9ADRD4POLBKMT2AMITF | |
| SCHEMBL1709220 | 0.86 | SCN9A (0.55) | SCN9ADRD4KMT2AMITF | |
| SCHEMBL10072166 | 0.84 | SCN9A (0.60) | SCN9ADRD4KMT2AMITFALDH1A1 | |
| SCHEMBL1286816 | 0.81 | DRD4 (0.62) | SCN9ADRD4 | |
| SCHEMBL10072407 | 0.80 | DRD4 (0.72) | DRD4 | |
| SCHEMBL1709222 | 0.80 | SCN9A (0.60) | SCN9ADRD4POLBKMT2AALDH1A1 | |
| SCHEMBL10072036 | 0.80 | SCN9A (0.55) | SCN9ADRD4POLBKMT2AMAPT | |
| SCHEMBL1709209 | 0.79 | SMN1; SMN2 (0.53) | SCN9ADRD4MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |